Substitution Reactions

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19 Terms

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Halogen

Nucleophile or leaving group

2
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Oxygen

Nucleophile

3
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Nitrogen

Nucleophile

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Sulfur

Nucleophile

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Cation

Electrophile

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Halides

Electrophile

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Water

Leaving group

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Carbon dioxide

Leaving group

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Nitrogen gas

Leaving groups

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Sulfates

Leaving group

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OMs (mesylate)

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OTs (tosylate)

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SN2 Stereochemistry

ALWAYS invert stereochemistry at carbon leaving group bond

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Diethyl ether (SN2 solvent)

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Ethyl acetate (SN2 solvent)

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Acetone (SN2 solvent)

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DMF (SN2 solvent)

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DMSO (SN2 solvent)

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ACN (SN2 solvent)