Antidepressants and Antipsychotics (Part 8)

Amitriptyline

Elavil

Tricyclic Antidepressants (TCAs)

• Older class of antidepressants

• Work by blocking the reabsorption of serotonin and norepinephrine

• Also affect acetylcholine and histamine levels; responsible for certain side effects and why TCAs may be used for conditions other than depression

Nortriptyline

Pamelor

Tricyclic Antidepressants (TCAs)

• Older class of antidepressants

• Work by blocking the reabsorption of serotonin and norepinephrine

• Also affect acetylcholine and histamine levels; responsible for certain side effects and why TCAs may be used for conditions other than depression

Mirtazapine

Remeron

Tetracyclic Antidepressants (TeCAs)

• Older class of antidepressants; similar in structure and action to the Tricyclic Antidepressants (TCAs)

• Exact mechanism is unknown; increase serotonin and norepinephrine

• Affect other neurotransmitters → side effects

Trazadone

Desyrel

Serotonin Antagonist and Reuptake Inhibitors (SARls)

• Work by blocking the binding, of serotonin at certain undesired receptors (serotonin antagonist) AND by blocking serotonin reabsorption (reuptake inhibitor); mechanism isn't completely understood

• Older class of antidepressants with less selectivity; affect other neurotransmitters (side effects, other use

• Often used for treatment of insomnia (off-label use)

Sertraline

Zoloft

Selective Serotonin Reuptake Inhibitors (SSRIs)

• Work by selectively blocking the reabsorption of serotonin; less side effects = most popular class

• Also used for a variety of anxiety-related disorders

Fluoxetine

Prozac

Selective Serotonin Reuptake Inhibitors (SSRIs)

• Work by selectively blocking the reabsorption of serotonin; less side effects = most popular class

• Also used for a variety of anxiety-related disorders

Paroxetine

Paxil

Selective Serotonin Reuptake Inhibitors (SSRIs)

• Work by selectively blocking the reabsorption of serotonin; less side effects = most popular class

• Also used for a variety of anxiety-related disorders

Citalopram

Celexa

Selective Serotonin Reuptake Inhibitors (SSRIs)

• Work by selectively blocking the reabsorption of serotonin; less side effects = most popular class

• Also used for a variety of anxiety-related disorders

Escitalopram

Lexapro

Selective Serotonin Reuptake Inhibitors (SSRIs)

• Work by selectively blocking the reabsorption of serotonin; less side effects = most popular class

• Also used for a variety of anxiety-related disorders

Venlafaxine

Effexor

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

• Work by selectively blocking the reabsorption of serotonin and norepinephrine

• In addition to depression, also used for anxiety disorders, nerve pain, and fibromyalgia

Duloxetine

Cymbalta

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

• Work by selectively blocking the reabsorption of serotonin and norepinephrine

• In addition to depression, also used for anxiety disorders, nerve pain, and fibromyalgia

Bupropion

Wellbutrin or Zyban

Norepinephrine Dopamine Reuptake Inhibitors (NDRIs)

• Work by selectively blocking the reabsorption of norepinephrine and dopamine

• In addition to depression, also used to help with smoking cessation

Risperidone

Risperdal

Atypical Antipsychotics (Second Generation, SGAs)

• Block dopamine receptors more selectively, which causes less EPS side effects

• Cause more weight gain than typical antipsychotics

• Only atypical antipsychotics in Top 200 drugs

Quetiapine

Seroquel

Atypical Antipsychotics (Second Generation, SGAs)

• Block dopamine receptors more selectively, which causes less EPS side effects

• Cause more weight gain than typical antipsychotics

• Only atypical antipsychotics in Top 200 drugs

Aripiprazole

Abilify

Atypical Antipsychotics (Second Generation, SGAs)

• Block dopamine receptors more selectively, which causes less EPS side effects

• Cause more weight gain than typical antipsychotics

• Only atypical antipsychotics in Top 200 drugs