Lecture 4- HLSC 3P09- Prolactin

What is Prolactin Produced by?

Lactotropes

What is Prolactin inhibited by?

Dopamine, which is a Prolactin Inhibiting Hormone

What is the main site of PRL action

Mammary Gland

What 3 things have to do with Lactation?

Mammogenesis, Lactogenesis, and Galactopoiesis.

What is Mammogenesis?

Growth and Development of the mammary gland

What is lactogenesis?

Initiation of lactation

What is Galactopoiesis?

Maintenance of Milk Production

What is PIH?

Prolactin Inhibiting Hormone

What is PRL?

Prolactin

What is PRFs?

Prolactin Releasing Factors

What do Estrogens do?

Stimulation of PRL gene expression

What is Menarche?

Puberty, and stimulates PRL secretion

In fetus, what stimulates IGF-II production?

PRL and hPL (human placental lactogen)

What happens when there is a deficiency in PRL

Inability of Initiate lactation and potential infertility in women.

Why does an increase in Prolactin cause infertility?

Inhibits the Gonadotropes, which reduces the secretion of LH and FSH, leading to disrupted ovulation.