HIV drug classes

Selzentry: generic, drug class, cycle inhibited, class wide effect

Maraviroc

CCR5 antagonist

Binding/attachement

BBW hepatotoxicity

Fuzeon: generic, drug class, cycle inhibited

Enfuvirtide

Fusion inhibitor

Fusion

treatment experienced only

Trogarzo: generic, drug class, cycle inhibited

Ibalizmuab

Post attachment inhibitor

Fusion

IV and treatment experienced only

Most common NRTIs

TDF, TAF, abacavir, lamivudine, emtricitabine

NRTI: cycle inhibited and class wide ADE

Reverse transcription

BBW: Lactic acidosis and hepatomegaly

side effects for emtricitabine

rash and hyperpigmentation (rare)

What is a CI for abacavir

HLA-B 5701 + allele

Most common NNRTIs (vir in middle of name)

Rilpivirine

Doravirine

Efavirenz

NNRTI: cycle inhibited and class wide effects

CYP inducers

hepatotoxicity and rash possible

which NNRTI needs to be taken with food

Rilpivirine

Why does Efavirenz need to be taken on empty stomach?

avoid neuropsych side effects

Most common Integrase inhibitors “INSTIs” (tegra in middle of name)

Bictegravir

Dolutegravir

Raltegravir

Elvitegravir

INSTIs: cycle inhibited and class wide effects

Integration

well tolerated, Elvitegravir may be CI in poor renal function

Most common Protease Inhibitors “PIs” (navir at end of name)

Atazanavir

Darunavir

Atazanavir and Darunavir side effects

Atazanavir - jaundice (bananavir)

Darunavir - sulfa allergy

PI: cycle inhibited and class wide effects

Budding and Maturation

Many due to PK boosters, hyperlipidemia, hyperglycemia, lipohypertrophy, insulin resistance 

Lencapavir: Brand, MOA, and dosing schedule

Sunlenca - for HIV treatment

Yeztugo - for PrEP

capsid inhibitor

Po then sq every 6 months

Cabennuva: generic and use

Cabotegravir and Rilpivirine

used for treatment

Apertude: generic and use

Cabotegravir alone

used for PrEP