biologic drugs

immune modulating drugs: alpha interferons drug moa indications contra

drug: pegasys

moa: inhibits intracellular replication of viral DNA

indication: tx of chronic hep B or C, hairy cell leukemia, kaposis sarcoma

contra: severe liver disease

immune modulating drugs: alpha interferons effects

SE: risk of infection, flulike sx, fever chills, HA, malaise

AE: seizures, neutropenia, neuropsychiatric disorder, tachycardia, ortho hypotension, confusion. 

immune modulating drugs: alpha interferons nursing

pregnancy category: C, if given with ribavrin X

labs: causes increases in triglycerides, LFTs and decreases in WBC, platelets, hgb

beta interferon drug moa indication contra

drug: avonex

moa: antiviral and immunomodulatory activity

indications: tx of relapsing multiple sclerosis

contra: allergy

beta interferon effects

SE: flulike sx, ha, malaise, myalgia

beta interferon nursing

dose: IM 30 mcg once a week 

pregnancy category: C

Gamma interferon drugs

only indicated for tx of serious infections with osteopetrosis and chronic granulomatous