Anthrax and Leprosy

Inhalation or GI Anthrax is treated with ___ in patient as first line?

Ciprofloxacin

What is given as second line for inhalation or GI anthrax in patients over the age of 12?

Doxycyline

What drugs are given in combination to the second line treatment for inhaled or GI anthrax?

Benzylpenicillin sodium, Clindamycin, Rifampicin, Vancomycin

What is another option given for GI or inhaled anthrax?

Amoxicillin and Imipenem with cilastatin OR meropenem and chloramphenicol

What is given for cutaneous anthrax as first line?

PO Ciprofloxacin

What is given for cutaneous anthrax as second line, in patients over the age of 12?

Doxycyline

What drugs given for leprosy?

Dapsone, Rifampicin and Clofazime

What other drugs are considered for leprosy?

Ofloxacin, Minocycline and Clarithromycin

A ___-drug regimen is recommended for multibaciliary leprosy.

Three

A __-drug regimen is recommended for paucibacilliary leprosy

What combination of antibiotics are given for multibacillary leprosy for 2 years?

Rifampicin, Dapsone, Clofazime

What drug does neurotic pain or weakness respond well to?

Prednisolone

What responses well to mild type II reactions?

Aspirin

What is provided in severe type II reactions, suggesting that the patient is already corticosteroid dependant in leprosy?

Thalidomide OR Increased Clofazimine dose

What is used to treat paucibacillary leprosy for 6 months?

Rifampicin and Dapsone

__ is used in caution in severe impairment

Clofazimine

Dapsone has an interaction with ___ with and increase levels of both when taken together.

Trimethoprim

__ leads to increased risk of blood disorders when taken long term leading to a fever, sore throat and rashes.

Dapsone

__ should not be given to patients who are under 12 and breastfeeding mothers due to risk of deposition in growing bone and teeth.

Minocycline

Patients who take __ should be monitored if they take it for longer than 6 months for hepatotoxicity, pigmentation and systemic lupus.

Minocycline

This drug should be taken with a full glass of water with sitting or standing.

Minocycline

Taking this drug with ___ can increase risk of ___ toxicity so it should be avoided, or dose reduced.

Lithium

Taking __ with minocycline can increase risk of benign intracranial hypertension.

Minocycline

Taking this drug increases risk of neutropenia and thrombocytopenia, rashes and is known to be teratogenic.

Thalidomide

Taking __ can increase risk of arterial and venous thromboembolism, with patients may requiring antithrombotic therapy prophylaxis

Thalidomide