Derm Drugs Pt 1

Antibacterial Agents, Acne Preparations, Azole Derivatives

What are the generic names for Neosporin?

Bacitracin, Neomycin, Polymixin B

What drug class is bacitracin, neomycin, and polymixin B (Neosporin)?

topical antibacterial agents

What are the indications for bacitracin, neomycin, and polymixin B (Neosporin)?

minor wounds, abrasions and scrapes

1st line tx for burns

What are the contraindications/cautions for bacitracin, neomycin, and polymixin B (Neosporin)?

N/A

Is there a black box warning for bacitracin, neomycin, polymixin B (Neosporin)?

No

What are the drug interactions for bacitracin, neomycin, polymixin B (Neosporin)

N/A

What are the adverse reactions for bacitracin, neomycin, polymixin B (Neosporin)?

contact irritation

What is the safety/monitoring for bacitracin, neomycin, polymixin B (Neosporin)?

N/A

What are the pregnancy/lactation terms for bacitracin, neomycin, polymixin B (Neosporin)?

may use

What is the MOA for bacitracin, neomycin, polymixin B (Neosporin)?

antibacterial

What is the brand name for mupirocin-pseudomonic acid A?

Bactroban

What drug class is mupirocin-pseudomonic acid A (Bactroban)?

topical antibacterial agents

What are the indications for mupirocin-pseudomonic acid A (Bactroban)?

MRSA infection, or other bacterial colonization

impetigo

What are the contraindications/cautions for mupirocin-pseudomonic acid A (Bactroban)?

if the wound is too large to cover

pt has a polyethylene glycol allergy

Is there a black box warning for mupirocin-pseudomonic acid A (Bactroban)?

No

What are the drug interactions for mupirocin-pseudomonic acid A (Bactroban)?

N/A

What are the adverse reactions for mupirocin-pseudomonic acid A (Bactroban)?

contact irritation, headache, nausea

What is the safety/monitoring for mupirocin-pseudomonic acid A (Bactroban)?

N/A

What are the pregnancy/lactation terms for mupirocin-pseudomonic acid A (Bactroban)?

may use

What is the MOA of mupirocin-pseudomonic acid A (Bactroban)?

inhibits protein synthesis

What are the generic names for Retin-A?

Retinoic Acid, Tretinoin, Trans-Retinoic Acid, Vitamin A

What drug class is retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)

topical acne preparation

What are the indications for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

acne, facial wrinkles

What are the contraindications for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

sun exposure

Is there a black box warning for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

No

What are the drug interactions for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

N/A

What are the adverse reactions for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

contact irritation, xeroderma, photosensitivity, sx may worsen before they get better

What is the safety/monitoring for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

N/A

What are the pregnancy/lactation terms for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

low risk teratogenicity, may use during lactation

What is the MOA for retinoic acid, tretinoin, trans-retinoic acid, vitamin A (Retin-A)?

stimulates epithelial cell turnover

What are the brand names for Isotretinoin?

Accutane, Absorica, Claravis

What drug class is isotretinoin (Accutane, Absorica, Claravis)?

oral acne preparation

What are the indications for isotretinoin (Accutane, Absorica, Claravis)?

severe recalcitrant acne, though not 1st line tx

What are the contraindications for isotretinoin (Accutane, Absorica, Claravis)?

osteomalacia, anorexia, DM, obesity, psych DO, hyperlipidemia, UV sun exposure

Is there a black box warning for isotretinoin (Accutane, Absorica, Claravis)?

YES

What is the black box warning for for isotretinoin (Accutane, Absorica, Claravis)?

pregnancy contraindication, iPLEDGE

What are the drug interactions for isotretinoin (Accutane, Absorica, Claravis)?

CYP3A4 substrates in liver

What are the adverse reactions for isotretinoin (Accutane, Absorica, Claravis)?

osteoporosis, dry mucous membranes, hypercholesterolemia, arthralgia, hepatotoxicity, skin irritation

What is the safety/monitoring for isotretinoin (Accutane, Absorica, Claravis)?

pregnancy test, LFTs, lipids, CBC, ESR, glucose, CPK, psych screening, vision changes, signs of pseudotumor cerebri, see pt regularly

What is the MOA for isotretinoin (Accutane, Absorica, Claravis)?

reduces sebaceous gland size and sebum production

What drug class is benzoyl peroxide?

topical acne preparation

What are the indications for benzoyl peroxide?

1st line tx for acne, rosacea

What are the contraindication/cautions for benzoyl peroxide?

photosensitivity, bleaching of skin, skin irritation

Is there a black box warning for benzoyl peroxide?

No

What are the drug interactions of benzoyl peroxide?

N/A

What are the adverse reactions for benzoyl peroxide?

contact irritation, nausea, headache

What is the safety/monitoring for benzoyl peroxide?

N/A

What are the pregnancy/lactation terms for benzoyl peroxide?

N/A

What is the MOA of benzoyl peroxide?

antimicrobial, peeling, antecomedolytic

What is the brand name for azelaic acid?

Finacea

What drug class is azelaic acid (Finacea)?

topical acne preparation

What are the indications for azelaic acid (Finacea)?

acne, rosacea

What are the contraindication/cautions for azelaic acid (Finacea)?

hypopigmentation possible

Is there a black box warning for azelaic acid (Finacea)?

No

What are the drug interactions for azelaic acid (Finacea)?

N/A

What are the adverse reactions for azelaic acid (Finacea)?

contact irritation

What is the safety/monitoring for azelaic acid (Finacea)?

N/A

What are the pregnancy/lactation terms for azelaic acid (Finacea)?

N/A

What is the MOA of azelaic acid (Finacea)?

antimicrobial, comedolytic

What is the brand name for clindamycin?

Cleocin

What drug class is clindamycin (Cleocin)?

topical acne preparation

What are the indication for clindamycin (Cleocin)?

acne, rosacea (OL), bacterial vaginosis, hidradenitis suppurativa (OL)

What are the contraindications for clindamycin (Cleocin)?

colitis possible

Is there a black box warning for clindamycin (Cleocin)?

No

What are the drug interactions of clindamycin (Cleocin)?

N/A

What are the adverse reactions to clindamycin (Cleocin)?

contact irritation

What is the safety/monitoring for clindamycin (Cleocin)?

N/A

What are the pregnancy/lactation terms for clindamycin (Cleocin)?

caution (weigh benefits vs risks)

What is the MOA for clindamycin (Cleocin)?

antimicrobial

What is the brand name for dapsone?

Aczone

What drug class is dapsone (Aczone)?

topical acne preparation

What are the indications for dapsone (Aczone)?

acne

What are the contraindications for dapsone (Aczone)?

methemoglobinemia, G6PD deficiency

Is there a black box warning for dapsone (Aczone)?

No

What are the drug interactions for dapsone (Aczone)?

benzoyl peroxide

What are the adverse reactions to dapsone (Aczone)?

contact irritation, peeling

What is the safety/monitoring for dapsone (Aczone)?

N/A

What are the pregnancy/lactation terms for dapsone (Aczone)?

unknown

What is the MOA for dapsone (Aczone)?

unknown

What are the brand names for metronidazole?

Metrogel, Metrocream

What drug class is metronidazole (Metrogel, Metrocream)?

Rosacea Tx

What are the indications for metronidazole (Metrogel, Metrocream)?

rosacea 1st line tx, bacterial vaginosis

What are the contraindications/cautions for metronidazole (Metrogel, Metrocream)?

N/A

Is there a black box warning for metronidazole (Metrogel, Metrocream)?

No

What are the drug interactions for metronidazole (Metrogel, Metrocream)?

benzoyl peroxide

What are the adverse reactions to metronidazole (Metrogel, Metrocream)?

contact irritation

What is the safety/monitoring for metronidazole (Metrogel, Metrocream)?

N/A

What are the pregnancy/lactation terms for metronidazole (Metrogel, Metrocream)?

depends on dose and use for pregnancy, discard milk

What is the MOA of metronidazole (Metrogel, Metrocream)?

antimicrobial, inhibits protein synthesis

What drug class do clotrimazole, econazole, ketoconazole, miconazole belong to?

topical azole derivatives

What are the indications for clotrimazole, econazole, ketoconazole, miconazole?

fungal infections

What are the contraindications for clotrimazole, econazole, ketoconazole, and miconazole?

if used vaginally, can weaken condoms

Is there a black box warning for clotrimazole, econazole, ketoconazole, and miconazole?

No

What are the drug interactions of clotrimazole, econazole, ketoconazole, and miconazole?

N/A

What are the adverse reactions of clotrimazole, econazole, ketoconazole, and miconazole?

contact irritation

What is the safety/monitoring for clotrimazole, econazole, ketoconazole, and miconazole?

N/A

What are the pregnancy/lactation terms for clotrimazole, econazole, ketoconazole, and miconazole?

may be used for nipple fungal infections

What is the MOA for clotrimazole, econazole, ketoconazole, and miconazole?

antifungal, increases cell wall permeability (rupture)

What drug class is griseofulvin?

oral azole derivative

What are the indications for griseofulvin?

specific to tinea capitis