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- glucose formed after digestion
- high concentration of glucose in lumen
- Na+ ions move down concentration gradient via facilitated diffusion to epithelial cells
- Na+ ions and glucose bind to protein, 2 Na+ ions and 1 glucose must bind before being transported across membrane
- Na+ ions actively transported out of epithelial cells through a protein carrier molecule (antiporter)
- maintains concentration gradient between lumen and epithelial cell in step 1