The Development of T Lymphocytes

Flashcards designed to review key concepts from the lecture notes on the development of T lymphocytes.

The development of T cells primarily occurs in the __.

thymus

Immature T cells are referred to as __ during their development in the thymus.

thymocytes

Positive selection in the thymus ensures that T cells recognize self-__ molecules.

MHC

T cells that do not recognize self-MHC during positive selection are signaled to __.

die

After positive selection, T cells differentiate into either CD4 or CD8 __ cells.

T

The process of __ selection eliminates T cells that bind too tightly to self-MHC.

negative

The gene rearrangement that leads to the formation of the T-cell receptor occurs in __ cells.

pre-T

The role of the cytokine __ in T-cell development is to signal the progenitor cells to support their growth.

interleukin-7 (IL-7)

Thymocytes entering the thymus as double-negative thymocytes do not express __ or CD8.

CD4

The process where T-cell precursors migrate from the bone marrow to the thymus is crucial for their __ development.

maturation

A specific structure in the thymus that removes improperly maturing T cells is known as __ corpuscles.

Hassall's

The two main lineages of T cells that develop in the thymus are __ cells and γδ T cells.

αβ

During the assembly of the pre-T-cell receptor, the β chain binds to a surrogate __ chain.

α (pTα)

Signals coming from the pre-T-cell receptor are dependent on the presence of CD4, CD8, the __ signaling complex, and ZAP70.

CD3

Negative selection in the thymus helps to produce __ tolerance in the T-cell repertoire.

central

After T-cell development, mature T cells leave the thymus and enter __ lymphoid tissue.

secondary

Regulatory T cells, or Treg cells, have a unique transcription factor called __.

FoxP3

Positive selection is influenced by peptides produced by the __ proteasome.

thymoproteasome