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Psychosis.
a. General term for breakdown of personality
b. Can be schizophrenia or the typical psychotic
c. Can be affective of mood disorder such as major depression and bipolar disorder
d. a and b
e. b and c
f. All
f. All
Schizophrenia is caused by increased
a. DA
b. 5-HT
c. Glutamate
d. a and b
e. b and c
f. All
f. All
Affective/Mood disorder is caused by decreased
a. DA
b. 5HT
c. NE
d. a and b
e. b and c
f. All
e. b and c
Drugs for Schizophrenia except:
a. Antipsychotics
b. Neuroleptics
c. Antischizophrenics
d. Major Tranquilizers
e. None
e. None
Antipsychotics has how many generations?
a. 1
b. 2
c. 3
d. 4
e. 5
b. 2
1st Generation Antipsychotics except:
I. Typical/Classical
II. D2 blockers
III. Greater D2 blockade than 5HT2A blockade
IV. Can cause extrapyramidal syndrome (EPS)
a. I, II, III, IV
b. I, II
c. I, II, III
d. II, III, IV
a. I, II, III, IV
Other effects of 1st generation antipsychotics.
a. Block histaminic receptors: Causing sedation
b. Block 𝛼 adrenoceptor: Like Alpha 1 → Vasodilation → Orthostatic hypotension
c. Block muscarinic receptors (Anti-cholinergic): Urinary retention
d. a and b
e. b and c
f. All
f. All - known as the Anti "H𝛼m" effect
2nd Generation Antipsychotics except:
I. Atypical/Newer
II. D4 and 5HT2A blockers
III. Greater D4 and 5HT2A blockade than D2 blockade
IV. Less risk for extrapyramidal syndrome (EPS)
a. I, II, III, IV
b. I, II
c. I, II, III
d. II, III, IV
a. I, II, III, IV
Treatment for positive symptoms of schizophrenia.
a. 1st generation antipsychotics
b. 2nd generation antipsychotics
a. 1st generation antipsychotics
Treatment for negative symptoms of schizophrenia.
a. 1st generation antipsychotics
b. 2nd generation antipsychotics
b. 2nd generation antipsychotics
Sub classifications of 1st generation antipsychotics.
a. Phenothiazines
b. Thioxanthene
c. Butyrophenone
d. a and b
e. b and c
f. All
f. All
1st generation antipsychotics.
I. Chlorpromazine
II. Fluphenazine
III. Thioridazine
IV. Thiothixene
V. Haloperidol
a. I, II, III, IV, V
b. I, II, III
c. III, IV, V
d. III
e. V
f. III, V
a. I, II, III, IV, V
Phenothiazine 1st generation antipsychotics.
I. Chlorpromazine
II. Fluphenazine
III. Thioridazine
IV. Thiothixene
V. Haloperidol
a. I, II, III, IV, V
b. I, II, III
c. III, IV, V
d. IV
e. V
f. III, V
b. I, II, III
Thioxanthene 1st generation antipsychotics.
I. Chlorpromazine
II. Fluphenazine
III. Thioridazine
IV. Thiothixene
V. Haloperidol
a. I, II, III, IV, V
b. I, II, III
c. III, IV, V
d. IV
e. V
f. III, V
d. IV
Butyrophenone 1st generation antipsychotics.
I. Chlorpromazine
II. Fluphenazine
III. Thioridazine
IV. Thiothixene
V. Haloperidol
a. I, II, III, IV, V
b. I, II, III
c. III, IV, V
d. IV
e. V
f. III, V
e. V
2nd generation antipsychotics.
I. Aripiprazole
II. Clozapine
III. Olanzapine
IV. Quetiapine
V. Risperidone
VI. Ziprasidone
a. I, II, III, IV, V
b. II, III, IV, V, VI
c. III, IV, V, VI
d. I, II, III, IV
e. I, II, III
f. I, II, III, IV, V, VI
f. I, II, III, IV, V, VI
Drugs for major depression.
I. Tricyclic Antidepressants
II. Selective Serotonin Reuptake Inhibitors (SSRI)
III. Atypical Antidepressants
IV. Monoamine Oxidase Inhibitors (MAOI)
a. I, II, III, IV
b. I, II
c. I, II, III
d. II, III, IV
a. I, II, III, IV
Mechanism of actions for depression.
a. Inhibit reuptake of Norepinephrine = increase norepinephrine
b. Blocking reuptake of serotonin = increase serotonin
c. Monoamine Oxidase Inhibitors
d. a and b
e. b and c
f. All
f. All
Inhibit reuptake of Norepinephrine.
a. Tricyclic Antidepressants
b. Selective Serotonin Reuptake Inhibitors (SSRI)
c. Atypical Antidepressants
d. Monoamine Oxidase Inhibitors (MAOI)
a. Tricyclic Antidepressants
Random and drug-unique MOA.
a. Tricyclic Antidepressants
b. Selective Serotonin Reuptake Inhibitors (SSRI)
c. Atypical Antidepressants
d. Monoamine Oxidase Inhibitors (MAOI)
c. Atypical Antidepressants
Also blocks dopamine receptors.
a. Amoxapine
b. Trazodone and Nefazodone
c. Mirtazapine
d. a and b
e. b and c
f. All
a. Amoxapine
Antagonists at postjunctional 5-HT2-receptors and also block prejunctional serotonin 5HT1-autoreceptors.
a. Amoxapine
b. Trazodone and Nefazodone
c. Mirtazapine
d. a and b
e. b and c
f. All
b. Trazodone and Nefazodone
Also has serotonin 5-HT2-receptor antagonist activity and also blocks alpha2-receptors.
a. Amoxapine
b. Trazodone and Nefazodone
c. Mirtazapine
d. a and b
e. b and c
f. All
c. Mirtazapine
Tricyclic Antidepressants (TCAs).
I. Inhibit reuptake of NE
II. Narrow therapeutic index
III. Include the -triptylline, and -pramine
IV. Has toxic effects including coma, convulsion, cardiotoxic
a. I, II, III, IV
b. I, II
c. I, II, III
d. II, III, IV
a. I, II, III, IV
Toxic effects of TCA except
a. Coma
b. Conjuctivitis
c. Convulsion
d. Cardiotoxic
e. None
b. Conjuctivitis
Tertiary amine TCA except:
a. Amitriptyline
b. Imipramine
c. Trimipramine
d. Doxepin
e. Clomipramine
f. Desipramine
f. Desipramine - this is secondary amine
Secondary amine TCA except:
a. Desipramine
b. Nortriptyline
c. Protriptyline
d. Amoxapine
e. None
d. Amoxapine - this is dibenzoxazepine
Dibenzoxazepine.
a. Desipramine
b. Nortriptyline
c. Protriptyline
d. Amoxapine
d. Amoxapine
Selective Serotonin Reuptake Inhibitors (SSRIs) except:
a. Inhibit the reuptake of 5HT only
b. Safer than TCAs
c. Increase suicidal thoughts, should be included in BBW
d. Interact with fluoxetine and paroxetine which are enzyme inhibitors
e. Interact with MAOIs causing Serotonin Syndrome
f. None
f. None
SSRIs.
I. Fluoxetine
II. Paroxetine
III. Duloxetine
IV. Citalopram
V. Escitalopram
VI. Fluvoxamine
VII. Sertraline
a. I, II, III, IV, V, VI, VII
b. I, II, III, IV, V, VI
c. II, III, IV, V, VI, VII
d. I, II, IV, V, VI, VII
e. I, III, IV, V, VI, VII
f. I, II, III, IV, VI, VII
d. I, II, IV, V, VI, VII
(III) Duloxetine is atypical antidepressant.
SSRIs except:
a. Fluoxetine
b. Paroxetine
c. Citalopram
d. Escitalopram
e. Duloxetine
f. None
e. Duloxetine
Atypical antidepressants.
I. Trazodone
II. Maprotiline
III. Bupropion
IV. Venlafaxine
V. Nefazodone
VI. Mirtazapine
VII. Duloxetine
a. I, II, III, IV, V, VI, VII
b. I, II, III, IV, V, VI
c. II, III, IV, V, VI, VII
d. I, II, IV, V, VI, VII
e. I, III, IV, V, VI, VII
f. I, II, III, IV, VI, VII
a. I, II, III, IV, V, VI, VII
Highly sedating atypical antidepressants except:
a. Trazodone
b. Nefazodone
c. Mirtazapine
d. Maprotiline
e. None
f. All
e. None
Atypical antidepressant that causes postural hypotension and priapism (sustained erection of penis).
a. Trazodone
b. Mirtazapine
c. Bupropion
d. Maprotiline
e. Amoxapine
a. Trazodone
Atypical antidepressant that causes marked weight gain.
a. Trazodone
b. Mirtazapine
c. Bupropion
d. Maprotiline
e. Amoxapine
b. Mirtazapine
Atypical antidepressant that may cause seizure; also used for smoking cessation.
a. Trazodone
b. Mirtazapine
c. Bupropion
d. Maprotiline
e. Amoxapine
c. Bupropion
Atypical antidepressant that may cause movement disorders.
a. Trazodone
b. Mirtazapine
c. Bupropion
d. Maprotiline
e. Amoxapine
e. Amoxapine
Atypical antidepressant that causes sexual disturbances, anxiety, and insomnia.
a. Bupropion
b. Maprotiline
c. Amoxapine
d. Venlafaxine
e. Duloxetine
d. Venlafaxine
Atypical antidepressant that causes GI disturbances, sexual dysfunction, insomnia, nausea.
a. Bupropion
b. Maprotiline
c. Amoxapine
d. Venlafaxine
e. Duloxetine
e. Duloxetine
Metabolizes Norepinephrine, Epinephrine, Serotonin.
a. MAOA
b. MAOB
a. MAOA
Metabolizes Dopamine only.
a. MAOA
b. MAOB
b. MAOB
MAO inhibitors.
I. Tranylcypromine
II. Isocaroxazid
III. Phenelzine
IV. Moclobemide
V. Selegiline
a. I, II, III, IV, V
b. I, II, III
c. IV
d. V
e. I, II, III
a. I, II, III, IV, V
Nonselective MAO inhibitors.
I. Tranylcypromine
II. Isocaroxazid
III. Phenelzine
IV. Moclobemide
V. Selegiline
a. I, II, III, IV, V
b. I, II, III
c. IV
d. V
e. I, II, III
b. I, II, III
MAOA selective inhibitors.
I. Tranylcypromine
II. Isocaroxazid
III. Phenelzine
IV. Moclobemide
V. Selegiline
a. I, II, III, IV, V
b. I, II, III
c. IV
d. V
e. I, II, III
c. IV - Moclobemide
MOAB selective inhibitors.
I. Tranylcypromine
II. Isocaroxazid
III. Phenelzine
IV. Moclobemide
V. Selegiline
a. I, II, III, IV, V
b. I, II, III
c. IV
d. V
e. I, II, III
d. V
MAO inhibitors not effective as antidepressant.
a. Tranylcypromine
b. Isocaroxazid
c. Phenelzine
d. Moclobemide
e. Selegiline
e. Selegiline
MAOIs interact with
a. Sympathomimetics like Tyramine
b. SSRIs, certain TCAs, and Meperidine
c. BRBs, Alcohol, Opioids
d. a and b
e. b and c
f. All
f. All
MAOIs drug interaction:
Hypertensive crisis.
a. Sympathomimetics like Tyramine
b. SSRIs, certain TCAs, and Meperidine
c. BRBs, Alcohol, Opioids
d. a and b
e. b and c
f. All
a. Sympathomimetics like Tyramine
MAOIs drug interaction:
Serotonin Syndrome.
a. Sympathomimetics
b. SSRIs, certain TCAs, and Meperidine
c. BRBs, Alcohol, Opioids
d. a and b
e. b and c
f. All
b. SSRIs, certain TCAs, and Meperidine
MAOIs drug interaction:
Additive sedation and CNS depression.
a. Sympathomimetics
b. SSRIs, certain TCAs, and Meperidine
c. BRBs, Alcohol, Opioids
d. a and b
e. b and c
f. All
c. BRBs, Alcohol, Opioids
Preferred for major depressive disorder.
a. TCA
b. Lithium
c. TCA and Atomoxetine
d. TCA and Venlafaxine
e. Imipramine
f. SSRI
f. SSRI
For bipolar disorder.
a. TCA
b. Lithium
c. TCA and Atomoxetine
d. TCA and Venlafaxine
e. Imipramine
f. SSRI
b. Lithium
For anxiety.
a. TCA
b. Lithium
c. TCA and Atomoxetine
d. TCA and Venlafaxine
e. Imipramine
f. SSRI
f. SSRI
For enuresis.
a. TCA
b. Lithium
c. TCA and Atomoxetine
d. TCA and Venlafaxine
e. Imipramine
f. SSRI
e. Imipramine
For ADHD.
a. TCA
b. Lithium
c. TCA and Atomoxetine
d. TCA and Venlafaxine
e. Imipramine
f. SSRI
c. TCA and Atomoxetine
For chronic pain.
a. TCA
b. Lithium
c. TCA and Atomoxetine
d. TCA and Venlafaxine
e. Imipramine
f. SSRI
d. TCA and Venlafaxine
Antidepressant agents are also used for bulemia and premenstrual dysphoric disorder.
a. True
b. False
a. True
Note 
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