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collagen
a strong fibrous protein made up mostly of glycine and proline amino acids
hydroxyapatite
the primary crystal of bone formed from calcium and phosphorus
trabecular or cancellous bone
less dense bone with a lattice-like structure. also called spongy bone
cortical bone
dense, strong bone that surrounds trabecular bone tissue. also called compact bone
osteoblasts
cells that build new bone tissue
osteoclasts
large cells that break down bone tissue
osteocytes
star-shaped cells that are the most abundant cell type in bone tissue
bone remodeling
process in which bone tissue is broken down and the rebuilt at the same location
bone resorption
process in which osteoclasts secrete hydrogen ions, which acidify the local environment and dissolve the minerals in the bone-tissue matrix
osteoid
bone tissue that is not mineralized
calcium
the most abundant mineral in mineralized bone tissue. good dietary sources of calcium are dairy products and many vegetables with low oxalate content, such as kale, collard greens, and okra
parathyroid hormone (PTH)
hormone acts to increase calcium levels in the blood
calcitriol
the active hormone produced by vitamin D that also helps to increase and regulate blood calcium levels
calcitonin
hormone that has the opposite effect of calcitriol and parathyroid hormones and aids in the maintenance of blood calcium levels by decreasing the calcium levels are necessary
vitamin D
both a vitamin and a hormone, vitamin D plays an essential role in maintaining calcium homeostasis. a deficiency in vitamin D compromises bone health
nutritional rickets
a childhood bone disease caused by a lack of vitamin D. it is characterized by soft, weak bones, that are susceptible to fracture
osteomalacia
similar to nutritional rickets, in adults this disease involves softening and weaking of the bones due to a lack of vitamin D or a problem metabolizing the vitamin
phosphorus
a mineral that makes up a substantial bone tissue. the dietary sources are non-genetically-modified soy, legumes, whole grains, dairy, nuts, and seeds
magnesium
a mineral that is a part of mineralized bone tissue. the dietary sources are meat, fish, dairy products, whole grains, nuts, chocolate, and coffee
fluoride
a mineral that blocks tooth decay and is part of mineralized bone tissue. the primary dietary source is fluoridated water
vitamin K
a vitamin that acts as a coenzyme that modifies proteins important for bone health. the dietary sources are green vegetables such as broccoli, cabbage, kale, parsely, spinach, and lettuce
osteoporosis
excessive bone loss over time
osteopenia
lower-than-normal bone mass
peak bone mass
the greatest amount of bone mass that a person reaches during their lifetime
bone mineral density (BMD)
measurement of the amount of calcified tissue in grams per centimeter squared of bone tissue
dual-energy X ray absorptiometry (DEXA)
a procedure during which two X-ray beams pass through a person and calculate the amount of calcified tissue in grams per unit area of bone
T-score
compares the patient’s BMD to the averaged BMD of a healthy thirty-year-old population of the same sex
risk factor
a variable that is linked to an increased probability of developing probability of developing a disease of adverse outcome
estrogen
primary female reproductive hormone
primary prevention
actions take to avoid developing a disease before it starts
secondary prevention
strategies focused on halting or reversing a disease after it has developed