BICD 110 Lecture 6 Golgi

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4 Terms

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Cisternal Maturation Model

The Golgi cisternae mature from cis to trans, enzymes are transferred between cisterne and the cargo does not move relative to the cisterna it’s in

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Vesicular Transport Model

The cisternae are static, and the enzymes stay in each cisterna. The cargo moves through cisternae through tubules and vesicles.

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Function of cis-Golgi

Remodeling of N-glycans
1) Removal of 3 Mannose by Mannosidase 1 and 2

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Function of medial Golgi

One GlcNAc added to N-glycan (transferred from UDP-GlcNAc), two more mannose resides removed