BLOOD VESSELS

Introduction, Disorders, and more

• Anticoagulant

• Procoagulant

• Fibrinolytic

Properties of blood vessels

All normal

In vascular disorders, what are the laboratory results of the ff.

• Platelet studies

• Blood coagulation

Mucosal surface bleeding

In vascular disorders, what are the symptoms?

1. HHT (Hereditary Hemorrhagic Telangiectasia) or ROWs (Rendu-Osler-Weber syndrome)

2. HT (Hemangiona Thrombocytopenia) or KMS (Kasabach-Merritt Syndrome)

3. EDS (Ehlers Danlos Syndrome)

4. Pseudoxanthoma elastic/ Homocystinuria

5. Marfan syndrome

6. Osteogenesis imperfect

What are the hereditary vascular disorders?

HHT or ROWS

A disorder with inadequate or missing elastin.

Telangiectasia

A disorder with dilated superficial blood vessels, characterised by small and focal red lesions.

ENG or ACVRL1

Gene mutation of HHT (ROWS)

Hemangioma thrombocytopenia (KMS)

A vascular disorder with tumor, thrombocytopenia, and bleeding diathesis.

• DIC

• Microangiopathic haemolytic anemia (MAHA)

Hemangioma thrombocytopenia (KMS) disorder association

Ehlers Danlos Syndrome

A disorder with defects in collagen production; characterised by hyper extensible skin, hyper mobile joints, and bleeding tendencies

1. Allergic purpura (Henoch Schonlein)

2. Drug-induced purpura

3. Vitamin C deficiency

4. Paraproteinemia and Amyloidosis

5. Senile purpura

6. Psychomatic origin

What are the acquired vascular disorders?

Allergic purpura (Henoch Schonlein)

An acquired vascular disorder that is associated with foods, drugs, colds, insect bites, and vaccinations. It is usually immune-mediated caused by too much IgA produced, being deposited in the blood vessels, causing vasculitis.

Drug-Induced Vascular Purpura

The mechanism of an acquired vascular disorder is the development of antibodies to the vessel wall components, which is frequently caused by drugs.

• Sulfonamides

• Iodides

What drugs are frequently causing drug-induced vascular purpura?

Collagen

Vitamin C deficiency/ Scurvy is caused by the decreased production of?

Perifollicular haemorrhage

What type of hemorrhage is seen in scurvy?

Senile purpura

This vascular disorder is common in elderly men, caused by decreased collagen production. This also causes increased capillary fragility.

• Thrombosis

• Hemorrhage

What blood disorder is associated with amyloidosis?

Psychomatic origin

What vascular origin is of equivocal origin, often caused by emotional problems.