Galactose Metabolism
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1. Galactose -->
Galactose 1-phosphate via galactokinase
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2. Galactose 1-phopshate + ______ -->
UDP-glucose --> Glucose 1-phosphate via glucose 1-phosphate uridyl transferase
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3. Glucose 1-phopshate -->
glucose 6-phosphate via phosphoglucomutase
- Enters glycolysis
- Enters glycolysis
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Now we need to regenerate...
UDP-glucose
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1. Galactose 1-phosphate -->
UDP-galactose
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2. UDP-galactose -->
UDP-glucose via UDP-glucose epimerase
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Deficiency in galactose 1-phosphate uridyl transferase results in
Cataracts due to build up of galactitol in lens causing water diffusing in to maintain osmotic balance