Antidepressants

Imipramine is considered an NE/5-HT reuptake inhibitor (NSRI), but has a higher affinity for SERT. How is this possible?

the demethylated metabolite is selective for NET

Which is non-TCA SNRI (selective for NE)?

B

Which is a common metabolic transformation for SSRIs?

dealkylation of a basic amine

if a patient takes imipramine, which other antidepressants will the patient test positive for in a drug test?

A

which is the most likely metabolite of desipramine?

A + D

which metabolite of citalopram likely has poor CNS penetration?

D

Which NSRI is least likely to cause QT prolongation?

C

the effect of an MAOI will diminish as soon as the drug is continued

false

Which metabolic event is very likely to occur with duloxetine?

n-dealkylation

which position on duloxetine is likely to undergo aromatic oxidation?

A

which position is most likely to undergo aromatic oxidation?

1

which is the most likely metabolite of clomipramine?

A

in the blood (pH = 7.4), SSRIs will most likely be ionized

true

SSRIs are best described as:

indirect agonists

Citalopram is formulated as the HBr salt. Which is the correct, formulated structure?

B

Which is an active metabolite of fluoxetine?

A

N-dealkylation is common for most SSRIs

true

Serotonin is the only important neurotransmitter in depression.

false

which is SERT selective?

A

which is NET selective?

C

which is not selective for SERT nor NET?

B