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Reproductive Physiology
The study of the mechanical, physical, and biochemical functions of the reproductive system
Andrology
Branch of repro physiology that deals with the study and treatment of male animals and humans
Gynecology
Deals with repro functions in women
Theriogenology
Branch of veterinary medicine that focuses on repro systems in animals
Obstetrics
Branch of repro physiology, vet medicine, and human medicine that specializes in the female before, during and after pregnancy
Aristotle
Generation of animals.
Conversion of blood by seminal fluid to create a fetus.
Proposed that a fetus came from menstrual blood
Fallopius
Described the oviducts
Coiter
Discovered the corpus luteum
Regnier de Graaf
Described the antral follicle. Killed rabbits and 1/2 hr after copulation. Discovered the number of scars on an ovaries corresponded to the number of embryos in the uterus.
Leeuwenhoek
Developed a simple microscope. Observed semen and discovered it had moving particles he named animalcules.
Spallanzani
Performed the first AI in a dog
Dumas
Discovered follicles contained ova.
Using rabbits he demonstrated that sperm were the fertilizing agents.
Sir Walter Heape
Transferred embryos in rabbits.
Serosa
Single cell layer of squamous cells that cover the outer surface of the tract.
Muscularis
Double layer of smooth muscle.
Outer longitudinal layer and inner circular layer.
Provides the ability to contract.
Transport of secretory products, gametes, embryos and expulsion of the fetus and membranes.
Submucosa
Laters of varying thickness.
Houses blood vessels, nerves and lymphatics.
Support tissue for mucosal layer.
Mucosa
Secretory layer of epithelium.
Each part of the tract is lined with a different type of epithelium.
Oviduct
Ciliated and non-ciliated columnar.
Produce fluid and move materials along oviduct.
Posterior vagina
Stratified squamous.
Provides protection during copulation.
Peritoneum
Membrane that lines the abdominal cavity.
Completely surrounds and covers the tract.
Broad ligament
The peritoneum eventually fuses to form a double layered connective tissue sheet that supports and suspends the tract.
Mesovarian
Supports the ovaries. Forms the hilus of the ovary.
Uterine-Ovarian ligament
Supportive ligament. Attaches the ovary to the uterus. Not a part of the broad ligament.
Mesosalpinx
Thin portion of the broad ligament that supports the oviduct.
Also forms a pouch that surrounds the ovary.
Mesometrium
Supports the uterine horns and body of the uterus.
Ovary
Dense structure. Produces female gametes and hormones.
Tunica albuguinea
Outer surface of the ovary. Connective tissue. Single layer of cuboidal cells.
Ovarian cortex
Houses the oocytes and follicles. Site of formation of the corpus hemorrhagicum, corpus luteum, and corpus albicans.
Corpus hemorrhagicum
Protrusion of tissue and ruptured blood vessels following ovulation.
Corpus luteum
Large structure that produces progesterone that is essential for pregnancy.
Yellow body.
Corpus albicans
White, scar like structures, CL in degeneration.
Connective tissue replacing secretory tissue.
Ovarian medulla
Central part of the ovary.
Houses vasculature, nerves and lymphatics.
Dense connective tissue.
Mare
Medulla and cortex are reversed. Cortex inside, medulla outside.
Ovulation occurs at one location-ovulation fossa.
Follicles can be palpated.
Folliculogenesis
The process of follicle development and maturation.
4 types of follicles
Primordial
Primary
Secondary
Tertiary
Primordial follicle
Microscopic, most immature.
Locate surrounded by a single layer of squamous cells.
Primary follicle
Oocyte surrounded by a single layer of cuboidal cells or follicular cells.
Do not divide - mature and degenerate.
Secondary follicle
Microscopic. 2 or more layers of follicular cells.
Characterized by being surrounded by a relatively thick translucent layer called the sons pellucida.
Tertiary or Antral follicle
Characterized by a fluid-filled cavity called the antrum.
When it becomes a dominant preovulatory follicle it can be called a Graafian follicle.
3 layers of antral follicle
Theca externa
Theca interna
Granulosal cell layer
Theca externa
Composed of loose connective tissue.
Completely surrounds and supports the follicle.
Theca internal
Just beneath the externa.
Responsible for the production of androgens under the influence of LH
Granulosa cells
Produce a variety of materials and have FSH receptors.
Estrogen
Inhibin
Follicular fluid
Infundibulum
Terminal end, funnel shaped opening.
Forms a pocket around the ovary.
Captures the ovulated oocyte.
Fimbriae
Fingerlike projections.
Increase surface area. Cause the infundibulum to slip over the entire ovary near ovulation.
Ampulla
Thick portion of the oviduct.
Occupies half of more of the oviduct length and is large in diameter.
Many fernlike mucosal folds with ciliated epithelium.
Ampullary-Isthmic junction
Site of fertilization.
Isthmus
Smaller in diameter. Thicker muscular wall than the ampulla with fewer folds.
Connected to the uterus. Uterotubal junction.
Uterus
Organ of pregnancy.
Connects oviduct to cervix.
Has 2 horns (cornua) in most mammals.
3 types- duplex, bicornuate, simplex.
Duplex uterus
Has two cervical canals that separate each uterine horn into distinct compartments.
Two types of duplex uterus
-single vaginal canal opening to the exterior that bifurcated into two vaginas and two cervices. Opossum
-two uterine horns and two crevices connected to a single vaginal canal. Rabbit
Bicornuate uterus
Uteri open into the vagina through a single cervical canal.
Two uterine horns and a small uterine body.
Horn length is dependent on the degree of fusion of the paramesonephric ducts.
Simplex uterus
Single uterine body without horns.
Small rudiments of a uterine horn may be present.
Fusion of the paramesonephric ducts is almost complete.
Primates and humans.
Perimetrium
Serosal layer.
Continuous with the mesosalpinx.
Thin and almost transparent.
Myometrium
Longitudinal and circular muscle layer.
Provides motility.
Expulsion of fetus and membranes during parturition.
Endometrium
Mucosa and submucosa.
Mucosa secretes materials into the lumen that enhance embryo development and sperm viability.
Sloughed to the exterior in primates.
Functionality of the glands change as a function of the estrous cycle.
Cervix
Thick walled, non-compliant, barrier to sperm transport.
Isolated uterus from external environment during pregnancy.
Highly viscous mucus.
Cow and Ewe cervix
Several of the rings form interlocking finger-like projections
Sow cervix
Rings interdigitate in a very intimate fashion.
Requires a penile adaption in the boar.
Corkscrew or spiral twist in the glans penis so it locks into the cervix.
Mares cervix
Loose folds of mucosa that protrude into the vagina.
Soft during estrus.
During copulation, the penis presses against the cervix and semen enters the uterus during ejaculation.
Functions of the cervix
Mucus flows from the cervix toward the exterior and lubricates the vagina during copulation.
Flushes out foreign material introduced during copulation.
Isolation of the conceptus within the uterus from the external environment.
Cervical seal of pregnancy.
Vagina
Serve as the copulatory organ.
Site for expulsion of urine during micturition.
Passive birth canal during parturition.
Cervix protrudes into this area forming a crypt (fornix)(absent in sow).
Caudal vagina
Belongs to both urinary and repro systems.
Protection during copulation.
Prevent microorganisma from getting to the vasculature in the submucosa.
Suburethral diverticulum
Blind pouch in the floor of the vestibule. Function unknown
Vestibular glands
Housed in the submucosa, caudal portion.
Secrete mucous-like material during estrus.
Vulva
External portion of the female repro tract.
Consist of 2 labia.
Form a closure to minimize entrance of foreign material.
Mostly adipose tissue, small amount of muscle - constrictor vulvae.
Perineum
Region that surrounds the vulva and anus and covers the pelvic outlet.
Bridge of skin between the anus and dorsal commissure.
Can tear during parturition.
Ventral commissure
Houses the clitoral fossa that contains the clitoris.
Female homolog to the penis.
Composed of erectile tissue and covered with squamous epithelium.
Well supplied with sensory nerve endings.