Dyslipidemia Agents

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24 Terms

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Fluvastatin (Lescol)

Statin

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Pravastatin (Pravachol)

Statin

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Lovastatin (Mevacor)

Statin

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Simvastatin (Zocor)

Statin

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Atorvastatin (Lipitor)

Statin

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Rosuvastatin (Crestor)

Statin

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Pitavastatin (Livalo)

Statin

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enter cells by passive diffusion, distribute widely to tissues, and are mainly metabolized by CPY450 enzymes

  • Fluvastatin (Lescol)

  • Lovastatin (Mevacor)

  • Simvastatin (Zocor)

  • Atorvastatin (Lipitor)

  • Pitavastatin (Livalo)

Lipophilic statins

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hepatoselective, require transporters for hepatic uptake, have limited extrahepatic distribution, and undergo minimal metabolism bf elimination 

  • Pravastatin (Pravachol)

  • Rosuvastatin (Crestor)

Hydrophilic statins

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zetia

Ezetimbe

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Alirocumab (Praluent)

PCSK9-Inhibitor

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Evolocumab (Repatha)

PCSK9-Inhibitor

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Inclisiran (Leqvio)

PCSK9-Inhibitor

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nicotinic acid, B-vitamin

Niacin

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Cholestyramine (Questran)

Bile Acid Sequestrants

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Colesevelam (Welchol)

Bile Acid Sequestrants

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Colestipol (Colestid) 

Bile Acid Sequestrants

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Nexletol

Bempedoic acid

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(Leqvio)

Inclisiran

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Evkeeza

Evinacumab

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Fenofibrate (Tricor, Trilipix)

Fibrates

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Gemfibroozil (Lopid)

Fibrates

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Lovaza (EPA + DHA)


Omega-3 Fatty Acids

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Vascepa (icosapent ethyl)


Omega-3 Fatty Acids

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