Gene therapy Vectors (MI 2.2.1)
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42 Terms
What is a plasmid?
A small, circular DNA molecule that can carry a gene of any size.
What type of DNA does a plasmid carry?
DNA
Does a plasmid have cell specificity?
No, it does not have cell specificity.
Does a plasmid trigger an immune response?
No, it doesn't trigger an immune response.
Does a plasmid integrate into the host cell genome?
No, it doesn't integrate into the host cell genome; it has temporary effects.
How efficient is a plasmid compared to other methods?
Less efficient.
What is a liposome?
A liposome is a spherical vesicle composed of lipid bilayers that can carry substances such as genes.
What can liposomes carry?
Liposomes can carry a gene of any size.
Do liposomes have cell specificity?
No, liposomes do not have cell specificity.
Do liposomes trigger an immune response?
No, liposomes do not trigger an immune response.
Do liposomes integrate into the host cell genome?
No, liposomes do not integrate into the host cell genome; they have temporary effects.
How efficient are liposomes in gene delivery?
Liposomes are less efficient in gene delivery.
What is the maximum length of a gene that the Herpes Virus can carry?
Up to 20,000 base pairs
What type of genetic material does the Herpes Virus carry?
DNA
What type of cells does the Herpes Virus infect?
Nervous cells only
Does the Herpes Virus trigger an immune response?
Yes, it triggers an immune response
Does the Herpes Virus integrate into the host cell genome?
No, it does not integrate (remains active in a cell)
How efficient is the Herpes Virus in terms of its infection process?
Less efficient
What is the maximum gene size that an Adeno-associated Virus can carry?
Up to 5,000 base pairs
What type of genetic material does Adeno-associated Virus carry?
DNA
Can Adeno-associated Virus enter both dividing and non-dividing cells?
Yes
Does Adeno-associated Virus trigger an immune response?
No
What is a key feature of Adeno-associated Virus regarding host cell genome integration?
It integrates into the host cell genome, providing long-lasting effects
Is Adeno-associated Virus considered efficient for gene delivery?
Yes
What is the maximum gene length that an adenovirus can carry?
7,500 base pairs
What type of genetic material does adenovirus carry?
DNA
What types of cells can adenovirus enter?
Dividing and non-dividing cells
What type of immune response does adenovirus trigger?
An immune response
Does adenovirus integrate into the host cell genome?
No, it has temporary effects
Is adenovirus considered efficient?
Yes
What type of genetic material do retroviruses carry?
RNA
What is the maximum length of a gene that a retrovirus can carry?
Up to 8,000 base pairs
Do retroviruses enter dividing or non-dividing cells?
Dividing cells
What type of immune response do retroviruses trigger?
An immune response
How do retroviruses integrate into the host cell genome?
Randomly
Are retroviruses considered efficient or less efficient?
Less efficient
What is the maximum gene length that a lentivirus can carry?
8,500 base pairs
What type of genetic material does a lentivirus carry?
RNA
What types of cells can a lentivirus enter?
Dividing and non-dividing cells
Does a lentivirus trigger an immune response?
No
How does a lentivirus integrate into the host cell genome?
Randomly
How efficient is a lentivirus for gene delivery?
Efficient
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