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What is a response of the body to any demand made on it?
Stress
what does the GAS theory consist of?
- alarm
- resistance
- exhaustion
What is activated in the alarm phase?
SNS
what is the goal of the resistance phase?
adaptation to avoid exhaustion
what term is defined as being resourceful, flexible, and having good problem solving skills?
resilience
what term is defined as commitment, control, and open to change?
Hardiness
How the patient sees the world and their place in it?
sense of coherence
what are the physiological manifestations of stress?
- decreased immunity
- increased inflammation
- increased blood sugar
What are methods of lowering stress?
- relaxation
- imagery
- meditation
- therapeutic touch
- 4x4 breathing
Where are WBC, RBC, and platelets produced?
bone marrow
What is the best location for aspiration?
- iliac crest
- sternum
What does a shift to the left in WBC indicate?
lots of WBC >10,000 but very immature - indicating a infection
What does a shift to the right in WBC indicate?
Few WBC <5,000, but very mature - indicates immunocompromised
What are the neutropenic precautions?
- hand washing
- isolation
- PPE
- screen/limit visitors
- no fresh flowers
- no produce
- temp check q2hrs
what are the critical values of platelets?
<10,000 or >1 million
what is the function of the spleen?
filters RBC's, takes Hgb from hemolysis and catabolizes the iron and sequesters PLTs and WBCs
what must be monitored following a splenectomy?
- infection
- bleeding
The rate a which RBCs settle in saline over the course of a period?
erythrocyte sedimentation rate (ESR)
An increased ESR would indicate what?
unspecified inflammation within the body
What is ferritin?
storage form of iron
A high ferritin would indicate what?
a high serum iron
The number of available proteins for iron to bind to?
total iron binding capacity (TIBC)
A high TIBC would indicate what?
low serum iron
What is the largest protein that binds with iron but is least preferred?
Transferrin
What measures the effectiveness of warfarin/coumadin?
PT and INR
What measures the effectiveness of heparin?
aPTT
A serious bleeding and thrombotic disorder that results from abnormally initiated and accelerated clotting?
disseminated intravascular coagulation (DIC)
What lab results would you expect from a pt with DIC?
- Low RBC
- High. plates
What type of hemophilia results from a deficiency in factor 8?
hemophilia A
how is hemophilia A and von williebrand disease treated?
DDAVP - vasoconstriction
What type of hemophilia results from a deficiency in factor 9?
hemophilia B (christmas disease)
What is the result of a deficiency in von willebran factor?
von willebrand disease
how long would you treat a hemophilia patient with a minor bleed?
72 hours
how long would you treat a hemophilia patient after surgery?
10-14 days
how should hemophiliac patients manage swollen joints?
rest, ice, pain meds, mobilization (NO ASA)
What are the s/s of iron deficiency anemia?
- pallor
- glossitis
- cheilitis
- burning tongue
How much iron supplements be taken?
one hour before meals with vitamin C
What are the s/s of thalassemia?
- thickening of the cranium and maxillary cavity
- hyperplasia bone marrow
- growth retardation
- bronze colored skin
when is the onset of minor thalassemia?
early adulthood
when is the onset of major thalassemia?
childhood
what type of autoimmune anemia occurs when the body does not produce enough intrinsic factor resulting in vitamin B deficiency?
cobalamin/pernicious anemia
Who is at risk for cobalamin/pernicious anemia?
- alcoholics
- pt with GI issues
how is cobalamin/pernicious anemia treated?
2 weeks of vitamin B12 injections
what is needed for DNA synthesis, RBC formation, and maturation?
folic acid
what type of anemia results in low WBC, RBC, and PLTs?
aplastic
What triggers sickling episodes?
low O2
what causes pain in sickle cell anemia?
vascular occlusion
how is sickle cell anemia treated?
- morphine or hydromorphone
- fluids
- rest
- oxygen
T/F: once initiation begins it cannot be stopped?
true
1 multiple choice option
what puts someone at risk for CA?
promoters
What is known to cause CA?
Carcinogens
T/F: The promotion phase of CA can be reversed?
True
1 multiple choice option
what are examples of promoters?
- dietary fat
- obesity
- smoking
- alcohol use
- UV exposure
What is defined as the seeding of tumor away from primary tumor usually via blood or lymph system?
metastasis
What are the most common sites of metastasis?
- bones
- brain
- adrenal
- liver
- lungs
How do CA cells escape and hide from the immune system?
via immunological escape
What CA markers are used to track tumor presence and development of how well tx is working?
oncofetal antigens
what prevents the immune system from attacking itself during passive immune system?
oncofetal antigens
from grade I to grade IV which are most differentiated to least?
Grade I = well differentiated
Grade II = moderate differentiated
Grade III = poorly differentiated
Grade IV- undifferentiated
What stage of CA is limited to the tissue of origin?
stage 1
what stage of CA is limited to local spread?
stage 2
what stage of CA has extensive local and regional spread?
stage 3
what stage of CA metastasis to other organs?
stage 4
What are the seven warning signs of CA?
- change in bowel/bladder
- a sore that does not heal
- unusual bleeding or discharge
- thickening lump in breast
- indigestion or difficulty swallowing
- obvious change in wart or nevi
- nagging cough or hoarseness
What are the goals of cancer treatment?
- cure
- control
- palliation
what must we consider when performing surgery on CA pt?
- self image
- body alteration
- recurrence
what education needs to be provided about chemo?
- anti emetics before therapy
- hair loss
- low energy activity
- 6 small high calorie, high protein meals per day
what education must be provided about radiation?
- no alcohol
- use warm/soapy water
- non scented
- gentle
- no swimming in chlorine or salt water
- gentle/loose fabric
- gentle detergent
- no sun exposure
- no excessive heat/cold
- observe site for infection
T/F: chemo rarely ever use only one method, almost always use 2+
true
1 multiple choice option
what are the s/s of AML?
- mouth sores
- bleeding
- lymphadenopathy
- sudden and dramatic onset with infection and bleeding
what are the s/s of ALL?
- pallor
- weight loss
- abdominal pain
- hepatosplenomegaly
what are the s/s of CML?
- sternal pain
- joint tenderness
- increased sweating
what symptom is associated with CLL?
anorexia
what CA is associated with reed-sternberg cells?
hodgkins lymphoma
what are some factors associated with hodgkins lymphoma?
- genetics
- toxic chemicals
- epstein barr virus (mono)
what are some s/s of multiple myeloma?
- bone marrow destruction
- hypercalcemia
- low PLTs
- low RBC
should you limit activity in fracture precautions, and why?
no because active bones absorb minerals