Innate Immune system

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10 Terms

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Main innate immune system responses

Physical barriers

Phagocytic cells

Natural Killer cells

Inflammation

Antimicrobial proteins

Fever

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Types of physical barriers

Skin

Hair

Mucus

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Major types of phagocytic cells

Neutrophils

Macrophages

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How do phagocytic cells know to kill pathogens?

Opsonization: marking of pathogens with proteins:

  1. Antibodies

  2. Complement proteins

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Natural killer cells

Non-phagocytic cells that attack cancerous or virally infected cells with vesicles.

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How do NK cells know which cells to kill?

Through checking Major histocompatibility complexes for either endogenous MHC proteins or exogenous MHC proteins.

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Antimicrobial proteins

Interferons, Complement proteins

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Interferons

proteins produced by infected cells that cause the production of Translation Inhibitory Proteins (TIPs), which inhibit viral replication

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Complement

A system of proteins that amplify the inflammatory response and kill pathogens.

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Complement Pathways

, Lectin, AlternativeClassical