FRCPath 1 Bone
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28 Terms
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Osteoma
Dense, mature bone, "ivory-like", "Gardner syndrome"
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Osteoid Osteoma
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Osteoblastoma
>2 cm, "expansile, soap-bubble", "posterior spine"
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Osteosarcoma (Conventional)
Malignant osteoid, "Codman's triangle", "sunburst periosteum", "teenagers, knee"
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Osteochondroma
Cartilage cap, "continuity with medulla", "sessile/pedunculated"
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Enchondroma
Mature hyaline cartilage, "lobulated", "central, hands/feet"
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Chondroblastoma
Epiphysis, "chicken-wire calcification", "Langerhans-like cells"
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Chondrosarcoma
Myxoid change, "binucleate chondrocytes", "entrapment", "pelvis"
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Non-Ossifying Fibroma
Fibrous histiocytes, "giant cells", "metaphysis, eccentric"
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Fibrous Dysplasia
Chinese characters, "ground-glass", "GNAS mutation"
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Simple Bone Cyst
Central, fluid-filled, "falling fragment sign", "proximal humerus"
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Aneurysmal Bone Cyst
Blood-filled spaces, "chicken-wire vessels", "USP6 rearrangement"
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Giant Cell Tumour of Bone
Epiphysis, "osteoclast-like giant cells", "mononuclear stroma", "H3.3 G34W"
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Tenosynovial Giant Cell Tumour
Multi-nucleated giant cells, "foamy histiocytes", "hemosiderin", "CSF1"
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Ewing Sarcoma
Small blue round cells, "CD99+ (membranous)", "EWSR1-FLI1", "onion-skin periostitis"
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Chordoma
Physaliferous cells, "notochord remnant", "sacrum/clivus", "brachyury+"
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Rheumatoid Arthritis
Pannus, "lymphoid aggregates", "neutrophils in synovial fluid"
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Gout
Negatively birefringent needles, "tophus", "monosodium urate"
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Pseudogout (CPPD)
Weakly positive birefringent rhomboids, "calcium pyrophosphate"
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Synovial Sarcoma
Monomorphic spindle cells, "biphasic/monophasic", "SS18-SSX", "TLE1+"
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Epiphysis: tumours for this location
Giant Cell Tumour, Chondroblastoma. location
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Metaphysis: tumours for this location
Osteosarcoma, Non-Ossifying Fibroma, Simple Bone Cyst. location
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Posterior Spine: tumour for this location
Osteoblastoma. location
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Codman's triangle, sunburst: Radiology
Osteosarcoma. Radiology
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Soap-bubble: Radiology
Giant Cell Tumour, Aneurysmal Bone Cyst. Radiology
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H3.3 G34W mutation is highly specific for molecular
Giant Cell Tumour of the Bone molecular
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CD99 membranous + EWSR1 rearrangement molecular
Ewing Sarcoma molecular
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Brachyury positive
Chordoma molecular
Note 
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