Innate Immune Cell Receptor Overview

PRRs

PRRs

Pattern Recognition Receptors, secrete cytokines which activate T and B cells, can be found membrane-bound or cytoplasmic

Clonal

Refers to “one type”, especially in cell receptors, displayed in all cells that encounter antigens

PAMP

Pathogen associated molecular pattern

MAMP

Microbe associated molecular pattern

DAMP

Damage associated molecular pattern

Toll-like receptor (TLR)

found in plasma membrane, endosomes, lysosomes

C-type lectin receptor (CLR)

found in plasma membrane

Retinoic acid-inducible gene-I (Rig-I)-like receptor (RLR)

found in cytosol

Nucleotide oligomerization domain (NOD)-like receptor

found in cytosol

Absent-in-melanoma (AIM)-like receptor (ALR)

found in cytosol and nucleus