viral replication

Where is the cell genome replicated?

Where is mRNA made?

Nucleus

Where is mRNA translated?

Cytoplasm

Where are proteins made in the cell?

Which organelle performs post translational modifications on proteins and transport them around the cell?

Spiked proteins

• Used for biding

No spike proteins uses capsids

Co-receptor

Binds primary receptor first and then co receptor

Irreversible attachment

Won’t go anywhere, Velcro

Fusion

• lipid bilayer merges

• Minimize contact w/ water

Acidication

• one shot to make sure it’s in the right place

Naked viruses do not undergo the process of uncoating

False - Nucleic acid is still inside the virus, need coat

Viruses are semi-conservative similarly to DNA

Makes reverse complement

Produce mRNA strands

Viruses don’t like to compete w/ cell for nutrients

Retroviruses and paravetrovirus both used

Reverse transcriptase big similarity

Reverse transcriptase

Uses RNA as a template

DNA to RNA

Transcription

RNA stays in cytoplasm

RNA viruses can replicate successfully in eunucleated cells

Not enough information

Antivirus attacks maturation cell

For HIV, Hep C, and paxolova?

Assembly

Capsids and ? Spontaneously create new Nucleic acids and nucleocapsid

Budding

Only envelope virus, pushes through membrane

Lysis & exocytosis

Available for other viruses

Performing an experiment, you enucleate some animal cells & infect them with a virus that you already learned has a linear DNA genome. What do you expect to find in these cells after a few days a time?

Your initial visions entered and uncoated, but no new viral genomes or proteins