Coagulation Cascade Practice Questions

1. Which of the following initiates the coagulation cascade IN VIVO?
A. Factor XII
B. Thrombin
C. Tissue factor
D. Factor X
E. Prekallikrein

C. Tissue Factor (III)

2. What does von Willebrand factor do?
A. Binds platelets to each other
B. Binds platelets to the subendothelium
C. Binds platelets to the phospholipid surface
D. Carries factor VII
E. Cleaves factor V

B. Binds platelets to the subendothelium

Which of the following is true?

A. The extrinsic system is activated first, and then the intrinsic system is turned on later
B. The intrinsic system is weak and short-lived
C. The extrinsic system is only important in vitro
D. Factors V and VII are only important in vitro

A. The extrinsic system is activated first, and then the intrinsic system is turned on later

4. Which anti-clotting substances act on factors V and VIII?
A. ATIII
B. Protein C
C. TFPI
D. Plasmin
E. t-PA

B. Protein C

5. Which of the following is a cofactor?
A. XII
B. X
C. VIII
D. VII
E. II

C. VIII

6. What are the ingredients in a PTT?
A. Â Plasma + phospholipid + calcium
B. Plasma + thromboplastin + calcium
C. Plasma + phospholipid + thromboplastin
D. Plasma + thrombin + calcium
E. Plasma + plasmin + calcium

A. Â Plasma + phospholipid + calcium

7. Which test evaluates the extrinsic pathway?

A. PT (INR)
B. PTT
C. TT
D. Closure time
E. Bleeding time

A. PT (INR)

8. Which of the following is true regarding the bleeding time?
A. It is a highly reliable and reproducible test
B. The sample is evaluated using an optical densitometer
C. It evaluates platelet function in vivo
D. It is a commonly ordered test
E. It evaluates the coagulation system

C. It evaluates platelet function in vivo

9. What is the most common inherited bleeding disorder?
A. von Willebrand’s disease
B. Hemophilia A
C. Hemophilia B
D. Factor V Leiden
E. TTP

A. Von Willebrand’s Disease

10. Which disorders may show “factor-type” Â bleeding?
A. von Willebrand’s disease
B. Hemophilia A
C. Both
D. Neither

C. Both

11. Patients with which of the following diseases may have a normal PTT?

A. von Willebrand’s disease
B. Hemophilia A
C. Hemophilia B
D. Factor V Leiden

A. von Willebrand’s disease

D. Factor V Leiden

12. Tissue plasmin activator _______________
a) helps in wound healing
b) allergy response
c) immunity
d) dissolves clots in blood vessels

d) dissolves clots in blood vessels

13. Which of the following will not coagulate when placed separately on four slides?
a) Blood serum
b) Blood plasma
c) Blood from the pulmonary vein
d) Blood from lymphatic tissue

A) Blood serum

14. The vitamin essential for blood clotting is _______
a) vitamin A
b) vitamin B
c) vitamin C
d) vitamin K

d) Vitamin K

15. What prevents clotting of blood in blood vessels?
a) Serotonin
b) Fibrinogen
c) Heparin
d) Fibrin

c) Heparin