Quiz 14 Krebs Cycle Set 02

What is the intermediate that is formed upon binding of pyruvate to PDH.

hydroxyethyl-TPP

The reaction of the citric acid cycle that is MOST similar to the pyruvate dehydrogenase complex-catalyzed conversion of pyruvate to acetyl-CoA is the conversion of:

a-ketoglutarate to succinyl-CoA

Why is the citric acid cycle considered to be part of aerobic metabolism, even though oxygen is NOT a substrate in any reaction?

because it produces NADH and FADH2, which ultimately transfer their electrons to oxygen

Which cofactor is required for the conversion of succinate to fumarate in the citric acid cycle?

FAD (flavin adenine dinucleotide)

Each molecule of acetyl-CoA oxidized by the citric acid results in the net production of _____ molecule(s) of _____.

FAD

Which combination of cofactors is involved in the conversion of pyruvate to acetyl-CoA?

TPP, lipoate, and NAD+

What intermediate is formed upon isomerization of citrate to isocitrate?

cis-aconitate

Which molecule(s) is an α-ketoacid?

oxaloacetate and α-ketoglutarate

Which enzyme catalyzes a hydration reaction?

fumarase

Entry of acetyl-CoA into the citric acid cycle is decreased when:

_____ is high

[ATP]