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Role of mitochondrial respiration during exercise
Produce long-term ATP and replenish PCr
ATP has what kind of supply
Limited
Mitochondrial respiration has what kind of supply
Virtually unlimited
Why is continuous synthesis of ATP necessary for muscle contraction?
muscle contraction can increase ATP demand by 100 so it must be continually synthesized to fuel activity
What are the three energy systems and which ones are considered anaerobic?
PCr (anaerobic) glycolysis (anaerobic), and mitochondrial respiration (aerobic)
How long can the PCr systems supply energy during an all out sprint ?
10 to 15 seconds
What is the role of mitochondrial respiration during exercise?
To produce long term ATP and replenish PCr
Stimulates metabolic pathways to speed up
High ADP levels
Causes hitting the wall
Low glycogen levels; forces slow fat oxidation
PCr system provides energy for…
2-3 seconds for max effort
Which energy system has the highest rate of ATP production
PCr
Entry point to TCA cycle
Acetyle CoA
Net ATP yield from glycolysis using blood glucose
2
Main reason fat is not used during high intensity exercise
Needs oxygen which is limited
Fat ____ is a ____ process requiring ____ amounts of ____ which ____ keep pace with the rapid energy demand
Metabolism, Slow, high, oxygen, cannot
Molecule that acts as the final electron receptor in the electron transport chain
Oxygen
How many ATP does complete oxidation of one glucose molecule produce
32
what stimulates energy production in the cell; turns pathways on
High ADP levels
Process that breakdown fatty acid into two carbon units
Beta oxidation
What is the body‘s main energy currency and how long is it stored for max efforts?
ATP ; 2-3 seconds
How long does the ATP PCR system last?
10-15 seconds
net ATP produced from glycolysis using blood glucose
2
net ATP from glycogen breakdown
3
The body’s primary way to store glucose for quick energy
Glycogen
Primary fuel source for producing ATP
Glucose
What is the rate limiting enzyme for glycolysis?
PFK
glycogen depletion causes…
“Hitting the wall”
Explain how the phosphine and oxidative systems work together
By providing immediate power for high intensity movement while simultaneously allowing the body to recover and prepare for future action
Define the crossover point
The intensity at which energy from carbs begin to dominate over energy from fat
What is the primary effect of endurance training on the crossover point?
The body can adapt to Use fat as a major fuel at higher intensities rather than carbs
Low intensity, long duration activities are fueled almost entirely by which system
Aerobic (mitochondrial respiration)
Lactate
Important fuel (not waste)
At low intensities, this is the main fuel source
Fat
At high intensities, this is the main fuel source
Carbs
The CP concept describes the shift from __ to __ as exercise intensity increases.
Fat, carbs
What causes the crossover shift toward carb use at higher intensities?
The activation of fast-twitch muscle fibers and higher muscle contraction intensity, which triggers rapid glycogen breakdown, and epinephrine (adrenaline) increases
endurance training shifts the crossover point in which direction?
Right (because trained athletes can work harder before switching to carbs)
Glycogen sparing occurs mainly because trained athletes….
can use more fat at a given workload, slowing glycogen use
At high exercise intensities, the main fuel source is:
Carbs
Lactate threshold represents the point where lactate :
Appears faster than it can be cleared
What is lactate’s primary role in the body during exercise?
Serves as a preferred fuel for many muscles like the brain and heart
The gas exchange threshold (GET) is detected when:
CO2 rises disproportionately
Critical power separates which two intensity domains
Severe and heavy
When exercising above CP, what happens
Vo2 keeps rising, PCr decreases, lactate accumulates, fatigue becomes inevitable
What causes glycogen sparing after endurance training
Increased fat oxidation and mitochondria
What is the primary role of phosphocreatine in the phosphate energy system?
to rapidly donate a phosphate group to ADP, reforming ATP for immediate use
Describe the relationship between the rate of ATP production and the total capacity of the body is three energy systems
Systems with the highest rate of ATP production, like the phosphogen system, have the most limited capacity
why is the gas exchange threshold valuable in clinical settings?
It’s effort independent, making it a reliable and objective measure of metabolic stress and surgical risk.
TCA cycle primary role
To complete the oxidation of acetyl-CoA and harvest high-energy electrons for the electron transport chain
Why does the complete oxidation of a fatty acid like palmitic acid yield more ATP than a molecule of glucose?
The breakdown of fatty acids produces a much larger number of acetyl-CoA molecules
the body’s most immediate source for regenerating ATP (type of system)
phosphagen system