Other MAJOR Blood Groups (ASCPi)

Lewis (ISBT 007)

It is the only blood group system not intrinsic to RBCs

Chromosome 19p13.3

Lewis gene is located at:

Leb

Which antigen is the receptor for Helicobacter pylori?

Le (a+b)

Non-secretor of ABH but sill secrete Lea

Le (a-b+)

Secretor; Lea-soluble and Leb-soluble antigens can be found in secretion and plasma

Le (a-b-)

Has nonfunctional Lewis transferase = bo expression of Lewis antigen on red cells (lele)

• Pregnancy

• Cancer

• Viral/Parasitic

• Alcoholic cirrhosis

Changes observed in the Lewis phenotype:

MN

Which antigens are found in Glycophorin A?

Ss

Which antigens are found in Glycophorin B?

Anti-M

Which MNS antibody reacts best at 6.5 pH?

Anti-N

Which MNS antibody may be found in renal patients under dialysis on equipment sterilized with formalin?

Anti-S and Anti-s

Which MNS antibody is IgG in nature, reacts best at 37°C, and can cause severe HTR and HDFN?

U antigen

This antigen is always present when S or s is inherited

• Hydatid cyst fluid

• Lumbricoides terestris

• Ascaris suum

P1 substance has been identified in:

Anti-P1

Which antibody is neutralized by hydatid cyst fluid from Echinococcus granulosus infection, pigeon droppings or turtle dove eggwhite?

Anti-Tja (Anti-PP1Pk)

• This antibody was discovered in the serum of patient “Mrs. Jay” w/ adenocarcinoma of stomach

  • Associated with increased incidence of spontaneous abortions in early pregnancy

Autoanti-P

This antibody is associated with PCH (Paroxysmal Cold Hemoglobinuria) and having a biphasic hemolysin Donath-Landsteiner Test

• Pyelonephritogenic E. coli

• Streptococcus suis

• Shigella dysenteriae

• Vibrio cholera

• Vibrio parahaemolyticus

Bacteria associated with P blood group system:

P antigen

Which antigen is a receptor for Parvo B19?

Human milk

I antigens can be neutralized with:

Cord blood cells

i antigen is found in:

Bombay phenotype

“I” activity is increased in individuals with:

Autoanti-I

• Antibody that is associated with Cold Agglutinin Syndrome

• Mycoplasma pneumonia infection (Primary Atypical Pneumonia) demonstrates high titer reactivity at 4°C and reacts over wide thermal range (up to 30-32°C)

Anti-i

This antibody is associated with infectious mononucleosis (EBV)

Kell antigen

It is considered the second most immunogenic antigen next to D antigen

Chromosome 7

KEL gene is found in:

McLeod phenotype

X-linked, and occurs when Kx and km antigen is not expressed and other Kell antigens are depressed

Chronic Granulomatous Disease (CGD)

McLeod phenotype is associated with:

Acanthocythic

In McLeod phenotype, RBCs are:

Anti-K

Along with Anti-D, this antibody is COMMONLY ENCOUNTERED in blood bank

Fya and Fyb

Which antigens serve as receptors for Plasmodium vivax and Plasmodium knowlesi?

Fy (a-b-)

Which antigen is associated with African Americans and confers resistance to Plasmodium vivax infections?

Anti-Fy3

It is the antibody made by Duffy Null phenotype

RBC urea transporter

The Kidd blood group system (ISBT 009) is located on:

Jk (a-b-)

Which antigen RBCs resist lysis in 2M urea?

Jk null

This antigen is abundant in Polynesians; also, been found in Filipinos, Indonesians, Chinese, and Japanese

• Enterococcus faecium

• Proteus mirabilis

• Micrococcus

Organisms with Jkb-like specificity include:

010

What is the ISBT number of the Lutheran blood group system?

Anti-Lua

Lutheran antibody that reacts well with saline, can produce mixed-field agglutination and it’s thermal optimum is 12-23OC

Anti-Lub

It is an incomplete Lutheran antibody; IgG - reacts better in AHG phase; clinically significant

Loose mixed-field agglutination pattern

Lutheran antibodies demonstrate a characteristic: