Looks like no one added any tags here yet for you.
Inhibition of which COX enzyme causes side effects
COX 1 inhibition causes side effects
COX 2 inhibition reduces inflammation
Anti inflammatory effects
COX inhibition
Limiting prostaglandins
RhoA inhibition
NGkB inhibition
PPAR activation
RhoA inhibition
GTPase that acitivates coiled protein kinase modifying myosin for contractions—> reducing is better bc less macrophages
What drugs do NFKB inhibition
Aspirin
Ibuprofen
Sulindac
What drugs activate PPAR
Aspirin
Indomethacin
Antipyretic effects of NSAIDs
Inhibition of PGE2 productionby COX enzymes reduces fever
NSAID antiplatelet effects
Non selective NSAIDs inhibit COX 1 reversiblly EXCEPT FOR ASPIRIN WHICH IS IRREVERSIBKE
What NSAIDs might have preventative benefits for alzheimers
Sulindac
Ibuprofen
Indomethacin
NSAID Side effects
GI upset
GI bleeding
Hypersensitivity
Decreased renal function
Cardio toxicity
Inhibition of uterine motility
Acetaminophen toxic metabolite
N acetyl p benzoquinone causes hepatotoxicity
What crosses the BBB more NSAIDs or acetaminophen?
Acetaminophen
Gold salts
Aurothioglucose, Gold sodium thiomalate, Auraanofin
Used as second line for rheumatoif arthritis
D Penicillamine
Decreases IL2, T cell numbers
Chelates trace metals
Used for rheumatoid arthritis
Omalizumab (Xolair)
Anti-IgE monoclonal antibody
Used for allergies & asthma
Zileuton
Inhibits 5-lipoxygenase long term production of leukotrienes
Long term asthma control only
Zafirlukast & Montelulkast
Competitive Luekotriene receptor blockers
Long term asthma symptom control