Lec 29-30

Inhibition of which COX enzyme causes side effects

COX 1 inhibition causes side effects

COX 2 inhibition reduces inflammation

Anti inflammatory effects

COX inhibition

Limiting prostaglandins

RhoA inhibition

NGkB inhibition
PPAR activation

RhoA inhibition

GTPase that acitivates coiled protein kinase modifying myosin for contractions—> reducing is better bc less macrophages

What drugs do NFKB inhibition

Aspirin

Ibuprofen

Sulindac

What drugs activate PPAR

Aspirin

Indomethacin

Antipyretic effects of NSAIDs

Inhibition of PGE2 productionby COX enzymes reduces fever

NSAID antiplatelet effects

Non selective NSAIDs inhibit COX 1 reversiblly EXCEPT FOR ASPIRIN WHICH IS IRREVERSIBKE

What NSAIDs might have preventative benefits for alzheimers

Sulindac

Ibuprofen

Indomethacin

NSAID Side effects

GI upset

GI bleeding

Hypersensitivity

Decreased renal function

Cardio toxicity

Inhibition of uterine motility

Acetaminophen toxic metabolite

N acetyl p benzoquinone causes hepatotoxicity

What crosses the BBB more NSAIDs or acetaminophen?

Acetaminophen

Gold salts

Aurothioglucose, Gold sodium thiomalate, Auraanofin

Used as second line for rheumatoif arthritis

D Penicillamine

Decreases IL2, T cell numbers

Chelates trace metals

Used for rheumatoid arthritis

Omalizumab (Xolair)

Anti-IgE monoclonal antibody

Used for allergies & asthma

Zileuton

Inhibits 5-lipoxygenase long term production of leukotrienes

Long term asthma control only

Zafirlukast & Montelulkast

Competitive Luekotriene receptor blockers

Long term asthma symptom control