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signals
Lactose absent
Lactose present, glucose present
Lactose present, glucose absent
Lactose absent, glucose absent
Lactose absent Lac Operon State
OFF
Lactose absent Reason
LacI binds operator; no allolactose to remove it
Lactose present, glucose present Lac Operon State
LOW (basal)
Lactose present, glucose present Reason
CRP-cAMP inactive (low cAMP); LacY blocked by inducer exclusion
Lactose present, glucose absent Lac Operon State
HIGH (fully ON)
Lactose present, glucose absent Reason
LacI released by allolactose; CRP-cAMP activates transcription
Lactose absent, glucose absent Lac Operon State
OFF (or very low)
Lactose absent, glucose absent Reason
No allolactose → LacI remains bound; CRP-cAMP present but repressor is activ