Primary hypothyroidism

Primary hypothyroidism

Inadequate production of thyroid hormones

Effects of primary hypothyroidism

Destruction or injury to thyroid

Inhibition of thyroid hormone synthesis

Resistance to thyroid hormone

Iodine deficiency (very common)

Etiology and pathogenesis of primary hypothyroidism

Hashimoto thyroiditis (autoimmune disorder)

• Inflammation and destruction to thyroid causes dysfunction

Diminished production of T3 and T4

Clinical manifestation of primary hypothyroidism

Weakness, Fatigue, Lethargy, Somnolence, mental slow

Muscle soreness, Cold intolerance, mood changes

Goiter, dry cold skin, hair loss

Delay in relaxation phase of deep tendon reflexes

Sinus bradycardia

Diagnosis of primary hypothyroidism

Serum FT4

TSH concentrations

Thyroid autoantibodies (test by antibodies)