Cell adhesion
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Where are cell adhesion molecules found in T-cell migration?
On both the T cell and the high endothelial venules (HEVs) of secondary lymphoid tissue.
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What process does T-cell adhesion resemble?
It mimics the rolling adhesion of neutrophils.
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What adhesion molecules are involved in the initial binding of T cells to endothelial cells?
L-selectin (on T cells) binds to CD34 and GlyCAM-1 (on endothelial cells).
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How does the T cell strengthen its adhesion to endothelial cells?
LFA-1 (on T cells) binds to ICAM-1 and ICAM-2 (on endothelial cells).
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