NURS 306 Insulin Medications

Rapid-Acting

Glulisine, Aspart, and Lispro

Glulisine, Aspart, and Lispro: onset

5-15 minutes

Glulisine, Aspart, and Lispro: peak

1-2 hours

Glulisine, Aspart, and Lispro: duration

2-5 hours

Short-Acting

Regular

Regular: onset

0.5-1 hour

Regular: peak 

2-3 hours 

Regular: duration

4-6 hours

Intermed-Acting

NPH

NPH: onset

1-2 hours 

NPH: peak

4-8 hours

NPH: duration

10-20 hours

Intermed/-Long-Acting 

Detemir 

Detemir: oneset

2-4 hours

Detemir: peak

6-8 hours (larger doses) and 3-4 hours (0.2-0.4 units/kg, smaller doses)

Detemir: duration 

5.7-23.2 hours 

Long-Acting 

Glargine and Degludec

Glargine: onset

1-2 hours

Glargine: peak

not significant (flat)

Glargine: duration

approximately 24 hours

Degludec: onset

1-2 hours

Degludec: peak

not significant (flat)

Degludec: duration

24-42 hours