Chapter 11a: Viruses

protects the viral genome and needs to be fully enclosed

protein coats

attachment has to happen when ?

the first stage of infection

presence or absence of lipid membrane

envelope

all viruses must make

mRNA that can be translated by host ribosomes

(5’-3’), ss+RNA means

ribosome ready

RNA + sense Viral Genome is

Transcribed

transcribes its RNA dependent RNA polymerase from its own genomic RNA in host cytoplasm

ssRNA + sense viruses

active RNA dependent RNA polymerase is packaged within the capsid and released in host cytoplasm

ssRNA - sense viruses

active reverse transcriptase packaged within the capsid where it reverse engineers its own dsDNA and released and integrated in host genome

ssRNA + sense with DNA intermediate viruses

has a receptor that a virus can attach to

susceptible cells

do not have the receptor for the virus to bind to

resistant cells

why viral and bacterial growth curves are different

human viruses have an eclipse period and bacteria don’t

viral growth lags because they must attach and enter first

6 step infectious cycle

attach, entry, uncoat, synthesis, assembly, release

what are the three ways virus enter

direct penetration, membrane fusion, endocytosis

the difference between an acute viral and a latent viral infection

acute infections release high virion from each infected cell

role of the TMPRSS2 enzyme

activates SARSCOV2 S-protein spike