SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS (SGLT-2) ORAL ANTIDIABETICS

what are the Sodium-glucose co-transporter 2 inhibitors (SGLT-2) medications?

class: Oral Antidiabetics

-gliflozin

• canagliflozin

• dapagliflozin

• empagliflozin

what is the mechanism of action of Sodium-glucose co-transporter 2 inhibitors (SGLT-2)?

• promote glucose excretion and ddecrease blood glucose levels

• increase water secretion

what are the indications for Sodium-glucose co-transporter 2 inhibitors (SGLT-2)?

• type 2 diabetes (oral antidiabetic)

• heart failure

• chronic kidney disease

what are adverse effects of Sodium-glucose co-transporter 2 inhibitors (SGLT-2)?

• urinary tract infections

  • urosepsis

  • pyelonephritis

• genital function infections (glucose in urine)

• increased urination and thirst

• dehydration and hypotension

• renal impairment

what are nursing interventions for Sodium-glucose co-transporter 2 inhibitors (SGLT-2)?

• monitor:

  • blood glucose levels

  • renal function

  • s/s of UTI or genital infections

  • signs of dehydration

• risk for hypotension with concurrent use of thiazide or loop diuretics

• teach good genital hygiene and adequate hydrate