Drug Metabolism + Elimination
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9 Terms
What is the point of drug metabolism?
To convert lipid soluble drugs to water soluble drugs.
What are prodrugs?
Drugs that enter as inactive form → gets metabolized into active form.
Do all drugs need to metabolized?
No, these drugs are called hard drugs.
What processes happen in phase 1?
Ozidation*
Hydrolysis
Reduction
What processes happen in phase 2?
Conjugation
What is the most important type of CYP450?
CYP3A4
What are enzyme inducers?
They are drugs that increase Hepatic enzymes function → increase drug metabolism
Nearly complete drug elimination occurs in —- half lives
4–5
The time needed to eliminate 50% of the blood plasma is called
Half-life or Plasma half-life
Note 
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