Ligand Gated Ion channels
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6 Terms
Ion channels
________
•Transmembrane proteins that allow selective ion movement
•Enable rapid electrical signaling in excitable tissues
•Ion movement follows electrochemical gradients
Channels are:
_____ selective
extremely fast
regulated (not passive pores)
ligand-gated ion channels
voltage-gated ion channels
leak channels
mechanically gated channels
Types of Ion Channels
_____
open w neurotransmitter binding
mediate synaptic transmission
_____
open w membrane depolarization
action potential
_____
always open
______
stretch/pressure, touch + hearing
Na+
K+
Ca2+
Cl-
_____ = depolarization
_____ = repolarization
_____ = secretion, contraction, signaling
_____ = inhibition + stabilization
affinity
efficacy
potency
Kd = how tight a drug binds (___)
Emax = maximal effect (___)
EC50 = how much drug is needed (___)
Orthosteric modulation
Allosteric modulation
LGIC Families
Note 
Flashcards (20)