Pharmacology Exam #2 - NSAIDs & Rheumatology
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17 Terms
Only irreversible COX inhibitor?
Aspirin
Celecoxib (Celebrex) mechanism?
Selective COX-2 inhibitor
Common side effects of NSAIDs?
GI ulcers, Renal toxicity, CV risk
Acetaminophen (APAP) toxic metabolite?
NAPQI
Antidote for APAP overdose?
N-acetylcysteine (NAC)
Misoprostol (PGE1) primary use?
Prevent NSAID-induced ulcers
Alprostadil (PGE1) use in neonates?
Maintain Patent Ductus Arteriosus (PDA)
Latanoprost (PGF2a) use?
Glaucoma (increases outflow)
Methotrexate (MTX) mechanism?
Folic Acid Antagonist
Must-give supplement with Methotrexate?
Folic Acid
Hydroxychloroquine major side effect?
Retinal toxicity (eye exams needed)
Leflunomide (Arava) pregnancy status?
Highly teratogenic (Contraindicated)
Requirement before starting TNF-alpha inhibitors?
TB screening (PPD/QuantiFERON)
Mechanism of Adalimumab & Infliximab?
TNF-alpha inhibitors
Drug for Acute Gout attack?
Indomethacin or Colchicine
Chronic Gout prevention (XO inhibitor)?
Allopurinol
Probenecid mechanism?
Uricosuric (increases uric acid excretion)
