Pernicious Anemia (B12 deficiency)

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4 Terms

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Cause

Lack of intrinsic factor (autoimmune destruction of gastric mucosa or surgery)

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Symptoms

  • Glossitis (red, smooth tongue)

  • neuropathies (numbness, tingling, gait issues, memory problems)

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Diagnosis

  • Macrocytic

  • normochromic anemia

  • low serum B12

  • antibodies to intrinsic factor

  • gastric biopsy.

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Treatment

B12 supplementation.

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