Intro and drug use

Major species

cattle, pig, chicken, turkey

Minor species

sheep, goat, rabbit, other poultry, cervids, aquaculture, honey bees

Prohibited drugs

chloramphenicol, clenbuterol, diethylstilbestrol, vancomycin, nitrofurazone/furazolidone, adamantane and neuraminidase inhibitors in birds

Fluoroquinolone extralabel use

only use as labeled for cattle and swine

Sulfonamide extralabel use

not for use in lactating dairy cows

3rd gen cephalosporins extralabel use

use at label dose and route for major species

can be used for off-label indications

Medicated feed extralabel use

allowed for minor species but not major species

Phenylbutazone extralabel use

not for use in lactating dairy cattle

Lactating dairy cow

dairy breed, female, over 20 months of age

Guidelines for extralabel drug use

health and welfare of an animal is in jeopardy

valid VCP relationship and careful diagnosis

no currently marketed drug for the disease, recommended dose is ineffective

records to idenfity treated animal

significantly extend withdrawal period, no illegal residues

Labeled withdrawal time

time it takes for 99% of animals to deplete drug at labeled dosage to less than established tolerance

Determinants of withdrawal time

dose - more give, more time it takes to leave

rate of depletion - usually tested in muscle, liver, kidney

half-life - withdrawal time/3