tolerance, toxicity endpoint, toxicity rate

haha good luck memorising this dumbass

common oar contours for pelvis

• bladder

• rectum

• prostate

• lt and rt femoral heads and necks

• penile bulb

common oars for the chest

• lt and rt lungs

• combined lungs - gtv

• heart, contoured from the pulmonary artery to the apex

• oesophagus

• thecal sac

• thecal sac + 3mm prv

tolerance and toxicity endpoint for spinal cord

tolerance - max dose for 45-50Gy

toxicity rate - 0.2%

te - myelopathy

tolerance and toxicity end point for combined lungs

tolerance: V20 less than 20-30%

toxicity endpoint: symptomatic pneumonitis

toxicity rate: less than 20%

tolerance and toxicity endpoint for oesophagus

tolerance: mean or less than 34Gy

toxicity endpoint: grade 3+ esophagitis

toxicity rate: 5-20%

tolerance and toxicity end point for the liver

tolerance: mean dose of less than 30-32Gy

toxicity endpoint: radiation induced liver disease

toxicity rate: less than 5%

tolerance and toxicity endpoint for the heart

tolerance: V25 less than 10%

te: long term cardiac mortality

toxicity rate: less than 1%

tolerance: mean dose less than 26Gy

te: pericarditis

toxicity rate: less than 15%

tolerance and toxicity endpoint for spinal cord prv

tolerance: max dose of 48-55Gy

te: myelopathy

tolerance and toxicity endpoint for bilateral kidneys

tolerance: mean of 15-18Gy

te: clinical dysfunction

toxicity rate: less than 5%

mean heart dose when creating breast rt plan

mean dose of less than 2-5Gy

tolerance and te for small bowel (individual loops)

tol: V15 < 120cc

te: grade 3+ gi complications: severe diarrhoea, abdo pain, obstruction

tr: <10%

tolerance and te endpoint for small bowel bad (peritoneal cavity)

tol: V15 < 195cc

te: grade 3+ gi complications: severe diarrhoea, abdo pain, obstruction

tr: <20%

tol, te, tr of rectum

tol:
V50 < 50%
V60 < 35%
V65 < 25%
V75 < 15%

te: grade 3+ toxicity: rectal bleeding, sever diarrhoea, pain, obstruction

tr: <10%

tol, te and tr for bladder

tol:
V75 < 25%
V70 < 30%
V65 < 50%

te: grade 3+ toxicity: urinary complications: increased frequency and urgency, haematuria, ulceration

tr: <6%

tol, te and tr and penile bulb

tol: V50 < 90%

te: severe erectile dysfunction

tr: <35%

critical grade structure vs quality of life structure

critical grade: needed to survive and function

qol grade: still important, can survive without

volume based contraints are usually applied for…

parallel structures

max dose based constraints are usually for…

serial structures