anticancer - chemotherapy

cancer - targeting ____ cells

own

TI of many anticancer drugs is _____

1.5

_____ of regimes is most effective treatment

combination

cancer MOA

• ____ = cell dividing out of control

• ____= cell doesn’t maintain intended function

• ____= cell moved out to site and infiltrates other tissues

overgrowth, tumor/neoplasm, cancer

3 drug targets for anticancer drugs

mitosis, DNA synthesis, nonspecific

drugs that target mitosis

plant alkaloids

drugs that target DNA synthesis

antimetabolites

drugs that target nonspecific cell cycle

alkylating agents

antineoplastic drugs are toxic in ____ of cell cycle

any phse

Busulfan, Carmustine, Cyclophamide, Dacarzine, Lomustine, Mechlorethamine, Melphalan, Procarbazine, Streptozocin, Thiotepa

Alkylating agents

Alkylating agents

• _____

• ____ cell target

cyotoxic, nonspecific

Cytarabine, Floxuridine, Fludarabine, Fluorouracil, Mercaptopurine, Methotrexate, Thioguanine

antimetabolites

antimetabolites

• target _____ - ____ phase inhibitiors

• nucleotide ____/nucleic acid _____ inhibitors

DNA synthesis, s, analogs, synthesis

Docetaxel, Etoposide, Innotecan, Paclitaxel

plant alkaloids

plant alkaloids

• ____ toxicity

• inhibit _____

• ____ and ____ supression

low, M phase, anemia, immune

Bleomycin, Doxorubicin, Mitomycin

antineoplastics

antineoplastics

• ____ in any phase

• affect ___ and ____

toxic, lung, heart

3 other kinds of antineoplastics

monoclonal antibodies, heavy metal compounds, tyrosine kinase inhibitors

‘mab’

monoclonal antibodies

monoclonal antibodies

• ____

• ____ toxicity

• directed to malfunctioning ____

biologics, low, proteins

‘platin’

heavy metal compounds

Carboplatin, Cisplatin

heavy metal compounds

heavy metal compunds

• cause severe ____

• _____ induced

nausea, platinum

‘tinib’

tryosine kinase inhibitors

tryosine kinase inhibitors

• _____

• inhibit ____

biologics, cell division

Alemtuzumab, bevacizumab, cetuximab, gemtuzumab, rituximab

monoclonal antibodies

Carboplatin, Cisplatin

heavy metal compounds

Elrotinib, Geftinib, Imatinib

tyrosine kinase inhibitors