What do the Receptors/Targets Hit by Antidepressants Do?

antagonism unless otherwise noted

SERT (Seroton Transporter)

decreased 5HT reuptake into the presynaptic neuron

NET (Norepinephrine Transporter)

decreased NE reuptake into the presynaptic neuron

DAT (Dopamine Transporter)

decreased DA reuptake into the presynaptic neuron

5HT2A

• decreased s3xual dysfunction

• decreased insomnia

• decreased anxiety

• increased DA release

5HT2C

• decreased s3xual dysfunction

• decreased insomnia

• decreased anxiety

• increased release of NE and DA via decreased GABAergic neuron activity

H1 (Histamine Type 1)

drowsiness

α1 (alpha 1)

orthostatic hypotension

M1 (Muscarinic Type 1)

anti-cholengeric effects

Sodium Channel

decreased action potentials

σ1 (Sigma 1) - agonism

• potentiate neurite outgrowth

• improves cognitive deficits

NOS (Nitric Oxide Synthase)

s3xual dysfunction

5HT1A (Serotonin Auto-Receptor) - partial agonist

• decreased inhibition of 5HT release (compared to full agonist)

• increased downregulation of auto-receptors

5HT3

decreased nausea

NMDA Receptor

• inhibits GABA release

• increased BDNF

• increased synaptic growth and activity

α2 (alpha 2)

• increased NE release via antagonism of NE autoreceptor

5HT7

• increased dopamine signaling

• increased cognitive function