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tropane alkaloids
Alkaloids having pyrrolidine- and pyperidine condensated ring systems
main: nortropane, tropane, tropine
atropine
-ester of tropic acid (D and L) and tropine
-USE: dilatation of pupils, inhibits salivary and mucus glands
-IN: deadly nightshade=belladonna species (Solanaceae)
scopolamine
-IN: datura species
-USE: causes exhaustion, narcotic, excitement, nausea, vomiting
-known as devil’s breath
ecgonine
-naturally occuring → esterified with methanol and benzoic acid → cocaine
-IN: erythroxylon coca (leaves)
-Cocaine: local anesthetic, narcotic
quinine
-quinoline skeleton
-IN: cinchona bark
-USE: antimalarial
ephedrine
-phenylethylamine (from phenylalalnine) protoalkaloid
-USE: vasoconstrictor in nose drops and vasodilatator in asthma med
- IN: Ephedra vulgaris