Sleep Disorders Brand/Generic

Non-benzodiazepines hypnotics (NBH) MOA

Act selectively at benzodiazepine receptors to increase GABA which is an inhibitory neurotransmitter, resulting in CNS depression

NBH - Eszopiclone (C-IV)

Lunesta

NBH - Zolpidem (C-IV)

Ambien

NBH - Zaleplon (C-IV)

Sonata

Orexin Receptor Antagonists (ORA) MOA

Orexin neuropeptide promotes wakefulness, ORAs block the orexin neuropeptide system which causes drowsiness

ORA - Daridorexant

Quviviq

ORA - Lemborexant

DayVigo

ORA - Suvorexant

Belsomra

Melatonin Receptor Agonists MOA

Agonist at the melatonin receptors, MT1 and MT2 which promotes sleepiness and regulates circadian rhythm

MRA - Ramelteon

RozeremM

TCA - Doxepin

Silenor

Benzo - Temazepan

Restoril

Antihistamine - Diphenhydramine

Benadryl

Antihistamine - Doxylamine

Unisom

Stimulant - Modafanil (C-IV)

ProvigilS

Stimulant - Armodafinil (C-IV)

Nuvigil

Sodium Oxybate

Xyrem

Stimulant - Dextroamphetamine/amphetamine

Adderall

Stimulant - Methylphenidate

Ritalin