B Cell Activation - TI vs TD Antigens
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10 Terms
What provides signal 1 for B cell activation?
Antigen binding to BCR
What is a thymus independent (TI) antigen?
Activates B cells without T cell help
What antibody is produced in TI responses
IgM only
Why can’t TI responses class switch?
No T cell help
What are TI-1 antigens?
Antigens that activate BCR and innate receptors (LPS)
What are TI-2 antigens?
Repetitive epitopes that extensively cross-link BCRs
What is a thymus-dependent (TD) antigen?
Requires CD4+ help
Which interaction provides signal 2 in TD responses?
CD40-CD40L
Why are TD responses stronger?
Class switching, memory, affinity maturation
Which cells act as APCs for TS responses
B cells themselves
Note 
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