Le Cell ECM and Junctions

Which cells primarily synthesize and secrete the ECM?

Fibroblasts

Collagen is rich in histidine and hydroxyproline and is a triple-helical structure.

True

Collagen is made in which part of the cell?

Endoplasmic reticulum

Laminin binds collagen and:

Plasma membrane

__ is a calcium ion-dependent family of proteins involved in cell-cell adhesion.

Cadherins

Which ECM molecule provides tensile strength?

Collagen

Tight junctions hold cells together in a __ , restricting the movement of substances between them. Tight junctions are found in cells that line the __.

sheet; digestive tract

Adherens junctions are anchoring junctions that use the protein called __ to hold cells together by anchoring to the cells' actin networks. Adherens junctions are found in tissues that are subject to __ such as __ .

Cadherin; Mechanical stress; Muscle

Desmosomes are a type of anchoring junction that use __ to hold cells together by anchoring to the cellular __. For more stable cell-cell connections, they anchor to the cells' __.

Cadherin; Intermediate fibers; Cytoskeleton

Gap junctions are communicating junctions that use protein channels called __ to create passageways between cells. When the connexons of two adjacent cells are lined up, a __ is made between the cytoplasms of the two cells, and __ can pass freely between the cells. Gap junctions are found in animal cells.

Connexons; Direct connection; Small molecules / ions

Hemidesmosomes are anchoring junctions that use __ to hold cells to the __. Hemidesmosomes are found in epithelial cells, holding them to the __.

Integrin; Basement membrane; ECM

Which collagen type is most ridged and is very abundant in bones and tendon

Type 1

What is the role of matrix metalloprotease?

ECM Degradation, Tissue Remodeling, Cell Migration, Regulation