Pharm care 2 test - Diabetic

Type 1 diab

Body produces insufficient insuline due to immunity system killing beta cells

Type 2 diabetes

Tissue resitance to insulin leading to pancreatic beta cell dysfunction and red . in insulin prod.

Type 2 troubleshoot

Glucose - hydrophylic- need transporter so we can improve tissue sensitivity to insuline

increase insuline lvls or decrease glucose prod and absiorption from GIT

Oral Antidiabetics names mnemonic

Big Glistening sulces glide in DPP 4 for alpha

Biguanids ( Big)

various derivateives with lots of effects

METFORMIN : incrase tissue sensitivity, reduce glucose abs from GIT and reduce gluconeogenesis in liver ( Reduction CVS risk ) and no hypoglycemia

Glitazones ( GLIstening)

Rosi and Pia ( reduce insuline resitenec, reduce gluconeogenesis and increase insuline secretion )

Sulfonylureas ( SULc)

increase secretion of insuline and increased succeptibilit of beta cell to glucose TYPE 2 treatment ( Afects glycemia ) And lots of interactions ( warfarin) .. High protein binding

Glinids (GLIde)

increase secretion of insuline .. for HYPERGLYCEMIA patients —3 doses daily - induces hypoglycemia and vomitiong (Repa NATE(

Incretines ( INcretines)

GLP and GLE analogs

hormones from GIT endocrine cells —- increase insuline secretion - innactivated by DPP4 !

reduce apetite, reduce gluconeogenesis

increase insuline

Semaglutide ( Ozempic)

DPP4

inhibition of DPP4 — thus increae in incretines …

Intestinal Alpha glucosidase inh. ( Alpha)

inh digestion of carbs — reduce and slows abs of comple carbs but induces flatulance ( Osmotic diarhoea)