lec 10 - heterotypic interactions of the biology of angiogenesis

why is angiogenesis helpful for cancer?

to increase blood supply (O2 and nutrients) to meet the tumor’s demands

describe the composition of carcinomas and what this means for cancers

list the types of stromal cells

how can stomal cells be identified/distinguished from tumor cells

what is heterotypic signaling

how do cancers learn to release and respond to an array of different heterotypic signals?

go through the classical/normal stages of wound repair

what is the role of epithelial-mesenchymal transition in wound repair?

describe how platelets are involved in ECM remodeling

what is the role of matric metalloproteases (MMPs)?

what is the one MMP that is a transmembrane protein?

how is physical contraction done at the wound site?

describe desmoplastic stroma

describe cancer-associated fibroblasts (CAFs)

what is the role of CAF in cancer

how are capillaries made in angiogenesis? what cell types are involved

what happens to cancer cells far from blood vessels?

describe what occurs within 0.2 mm of a blood vessel

what happens to cells suffering from hypoxia?

why is vasculature needed? how do capillary networks compare between normal and tumor tissues?

how do pericytes and smooth muscle cells cover normal blood vessels?

how do pericytes and smooth muscle cells cover tumor associated blood vessels?

describe the organization of tumor-associated blood vessels

are tumor associated blood vessels more leaky or restrictive than normal tissue-associated blood vessels

how is microvessel density related to prognosis

how do tumors stimulate angiogenesis

what is the key biochemical pathway that starts angiogenesis? HINT: HIF-1apla

name some angiogenic activators and inhibitors

can angiogenesis be targeted in cancer therapy?