Site specific Drug delivery - unfinished

Do part 1 lecture here

Lecture 2

How does tumour vasculature differ from normal vasculature?

Tumour blood vessels are leaky, impaired, non-uniform, and more distributed due to rapid growth.

Loose connections between endothelial cells and pericytes create gaps, allowing macromolecules to escape.

Why is nanoparticle size and surface property control important in drug delivery?

Optimal size (<100nm) maximises circulation time and tumour targeting.

A hydrophilic surface prevents rapid clearance by the mononuclear phagocyte system (MPS) and macrophages.

How can nanoparticles be designed to evade immune clearance?

Coating with hydrophilic polymers (e.g., PEG) prevents plasma protein adsorption and macrophage recognition.

Liposomes coated with PEG can evade MPS clearance, improving drug delivery efficiency.

What are the enhanced permeation and retention (EPR) effects in tumours?

Enhanced permeation: Leaky tumour blood vessels allow nanoparticles and macromolecules to pass through.

Enhanced retention: Damaged lymphatic drainage leads to drug and nanoparticle accumulation at the tumour site.