Hemostasis (Blood Coagulation)

First Step

Vascular Spasm:
Injury to the blood vessel causes damage to the endothelial cells lining the vessel. In response, these cells contract and release chemicals to make the muscles within the walls of the blood vessel contract. This also results in cell division and the release of other proteins that attract other blood cells to the area. Additionally, they release von Willebrand Factor which makes the endothelial cells “sticky” so that recruited cells can begin to seal up the damaged blood vessel.

Second Step

Formation of a Platelet Plug:

Platelets begin to adhere to the von Willebrand Factor. Platelets begin to aggregate and form a platelet plug, which further seals the injured area. They then begin to contract, pulling the injured tissues together. This clot, also called a thrombus, consists mostly of a protein called fibrin. The purpose of this protein is to reinforce the platelet plug and solidify any remaining blood in the injured area. Activated platelets also release pro-clotting factors in preparation for the blood coagulation stage.

Platelet Plug/ Clot Formation

Blood coagulates, forming a scab and sealing the injured blood vessel. A protein called fibrin stabilizes the clot and keeps it in the wound

Thats all

thats all